Management guidelines for uninvestigated and functional dyspepsia in the Asia-Pacific region: First Asian Pacific Working Party on Functional Dyspepsia

Journal of Gastroenterology and Hepatology
N J TalleyK M Fock

Abstract

Dyspepsia is most optimally defined as pain or discomfort centred in the upper abdomen. The symptom complex may be caused by peptic ulcer disease, gastro-oesophageal reflux, or gastric cancer but is most often due to functional (or non-ulcer) dyspepsia. While upper endoscopy is the method of choice to determine the underlying cause of dyspepsia, it is expensive. A more pragmatic approach is needed in the Asia Pacific region where health services are limited. A detailed treatment algorithm is given for managing patients presenting with new-onset dyspepsia and documented functional dyspepsia after endoscopy, and evidence to support this approach is reviewed. Prompt endoscopy is recommended for patients with alarm features. In patients without alarm features, treatment for 2-4 weeks with an empirical anti-secretory or prokinetic agent, followed by investigation using non-invasive Helicobacter pylori testing and treatment for patients who do not respond or relapse, is recommended. Trials of management strategies are now needed to establish the efficacy and cost-effectiveness of the approaches recommended.

References

Jul 15, 1992·American Journal of Epidemiology·N J TalleyL J Melton
Jan 1, 1992·Scandinavian Journal of Gastroenterology·T JohannessenI Løge
Nov 16, 1991·BMJ : British Medical Journal·S PatchettC O'Morain
Jan 1, 1991·Scandinavian Journal of Gastroenterology. Supplement·R C Heading
Jan 1, 1991·Scandinavian Journal of Gastroenterology. Supplement·J E Richter
Jan 1, 1991·Scandinavian Journal of Gastroenterology. Supplement·R P Knill-Jones
Jan 1, 1991·Scandinavian Journal of Gastroenterology. Supplement·O Nyrén
Jan 27, 1990·Lancet·A G KlauserS A Müller-Lissner
Feb 10, 1990·BMJ : British Medical Journal·D D KerriganG H Hutchinson
Apr 1, 1990·Gut·R H JonesJ M Bottomley
Aug 15, 1988·International Journal of Cancer. Journal International Du Cancer·H P LeeK Shanmugaratnam
Oct 26, 1974·British Medical Journal·R J BarnesA B Dew
Jun 1, 1995·Scandinavian Journal of Gastroenterology·A al-QuorainF al-Shedoki
Apr 1, 1995·Alimentary Pharmacology & Therapeutics·N J Talley
Apr 1, 1995·Alimentary Pharmacology & Therapeutics·J E KellowS K Lam
Sep 1, 1995·Gastroenterology·L R HanssonA Lindgren
Jun 1, 1993·Drugs·Gerald Holtmann, Nicholas J Talley
Jan 1, 1995·Journal of Psychosomatic Research·B H JonssonR Gotthard
Jan 1, 1995·Digestive Diseases and Sciences·C McCarthyC O'Morain
Mar 1, 1995·Gastroenterology·E A Mayer
Feb 1, 1995·Gut·P K SmallF C Campbell
Apr 2, 1994·Lancet·P BytzerO B Schaffalitzky de Muckadell
Jan 1, 1994·Scandinavian Journal of Gastroenterology·I Fumagalli, B Hammer
Jan 1, 1993·Scandinavian Journal of Gastroenterology. Supplement·H Petersen
Apr 1, 1993·Scandinavian Journal of Gastroenterology·L P DuanY N Li
Jan 1, 1993·Scandinavian Journal of Gastroenterology. Supplement·J M Chung
Jan 1, 1993·Scandinavian Journal of Gastroenterology. Supplement·M InoueA Miyoshi
Jan 1, 1993·Scandinavian Journal of Gastroenterology. Supplement·M Van OutryveJ P Gooris
Jan 1, 1993·Scandinavian Journal of Gastroenterology. Supplement·S F WoodK M Cochran
Nov 1, 1995·Journal of Gastroenterology and Hepatology·R J SchlemperC B Lamers

❮ Previous
Next ❯

Citations

May 1, 2007·European Journal of Clinical Pharmacology·Juan ZengGuo-Ping Lv
Oct 4, 2002·Comprehensive Therapy·Shehan Abeygunasekera, Nicholas J Talley
Mar 29, 2013·Clinical and Translational Gastroenterology·Javier P Gisbert, Xavier Calvet
Mar 29, 2001·Journal of Clinical Gastroenterology·N J Talley
Dec 17, 2009·Journal of Clinical Gastroenterology·David Yates Graham, Massimo Rugge
Feb 1, 2007·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Roslan A RahmanRoszalina Ramli
Nov 16, 2005·Gastroenterology·Nicholas J TalleyPaul Moayyedi
Jan 15, 2015·Journal of Gastroenterology·Hiroto MiwaUNKNOWN Japanese Society of Gastroenterology
Sep 26, 2002·Gastrointestinal Endoscopy·Chun Tao WaiSeng Gee Lim
Feb 6, 1999·The American Journal of Gastroenterology·F MearinJ R Malagelada
Aug 22, 2001·The American Journal of Gastroenterology·F FroehlichUNKNOWN Eradication in Dyspepsia (ERADYS) Study Group
Aug 19, 2000·The American Journal of Gastroenterology·C R LockeL J Melton
Jun 25, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·B GermanáA Franzé
Jun 26, 2001·Symposium Series·J G Kusters, E J Kuipers
Aug 13, 1999·The American Journal of Gastroenterology·V StanghelliniR Corinaldesi
Oct 30, 2004·Scandinavian Journal of Gastroenterology·N J TalleyL Agréus
Dec 25, 2010·Therapeutic Advances in Gastroenterology·R Christopher Harmon, David A Peura
Aug 23, 2002·The American Journal of Gastroenterology·Walter L StrausPaul Shekelle
Jun 27, 2002·Journal of Gastroenterology and Hepatology·Wayne H C HuShiu-kum Lam
Feb 26, 2011·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Sam Ryong JeeUNKNOWN Korean Society of Neurogastroenterology and Motility
Mar 6, 2007·The American Journal of Gastroenterology·Joseph Sung
May 9, 2008·Digestive Diseases·Alexander C Ford, Paul Moayyedi
Aug 11, 2010·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Hye-kyung JungUNKNOWN Korean Society of Neurogastroenterology and Motility
Oct 5, 2010·Internal and Emergency Medicine·Luigi GattaDino Vaira
Dec 13, 2019·BMJ : British Medical Journal·Leonardo H EusebiAlexander C Ford
Jan 10, 2020·Journal of Neurogastroenterology and Motility·Jung Hwan OhUNKNOWN Functional Dyspepsia Research Group and Clinical Practice Guidelines Group Under the Korean Society of Neurogastroenterology
Mar 28, 2008·Scandinavian Journal of Gastroenterology·Shweta TripathiKartar Singh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.