Management of 273 cases of recurrent implantation failure: results of a combined evidence-based protocol

Reproductive Biomedicine Online
K W Sharif, S Ghunaim

Abstract

This study evaluated the results of a management protocol combining a number of investigations and interventions, previously proven beneficial in randomized controlled trials in IVF/intracytoplasmic sperm injection (ICSI) patients with apparently unexplained recurrent implantation failure (defined as two or more previous failed cycles, during which at least six good-quality embryos were transferred). It was a prospective cohort study and included 273 couples with previous recurrent implantation failure. Each patient (all under 40) underwent a pre-treatment work-up, consisting of pelvic ultrasound scan for hydrosalpinx, hysteroscopy and screening for acquired and congenital thrombophilia. Detected abnormalities were dealt with accordingly: proximal occlusion for hydrosalpinx, hysteroscopic management for intrauterine pathology and thromboprophylaxis with daily low-molecular weight heparin from the day of embryo transfer for thrombophilia. The patients then underwent IVF/ICSI with laser-assisted hatching. 112 patients (41%; group 1) had abnormalities detected (17 hydrosalpinx, 11 intrauterine pathology, 63 congenital thrombophilia, 21 acquired thrombophilia) and the remaining 161 (59%; group 2) had normal work-up. The pregnancy r...Continue Reading

References

Aug 1, 1991·Journal of in Vitro Fertilization and Embryo Transfer : IVF·J Cohen
Mar 24, 1998·Reviews of Reproduction·A Sharkey
Apr 9, 1998·Fertility and Sterility·K SharifL Sinclair
Aug 6, 1998·British Journal of Obstetrics and Gynaecology·S LaveryR Winston
Oct 10, 2001·Human Fertility : Journal of the British Fertility Society·D SakkasM Afnan
May 1, 2002·Human Reproduction·R T Mansour, M A Aboulghar
May 21, 2004·Reproductive Biomedicine Online·Aygul Demirol, Timur Gurgan
Mar 8, 2005·Fertility and Sterility·Siobhan QuenbyGill Vince
Jun 1, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Bee K TanStephen D Keay
Mar 30, 2006·Reproductive Biomedicine Online·Tarek El-Toukhy, Mohamed Taranissi
Jun 9, 2006·Fertility and Sterility·UNKNOWN International Committee for Monitoring Assisted Reproductive TechnologyFernando Zegers-Hochschild
Jul 6, 2006·Reproductive Biomedicine Online·Ole B ChristiansenAstrid M Kolte
Jul 13, 2006·Human Reproduction·Hussein S QublanYousef S Khader
Aug 15, 2006·Human Reproduction·E J MargaliothT Eldar-Geva
Feb 6, 2007·Fertility and Sterility·UNKNOWN Society for Assisted Reproductive Technology, UNKNOWN American Society for Reproductive Medicine
Mar 17, 2007·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·J GraceY Khalaf
Jul 13, 2007·Current Opinion in Obstetrics & Gynecology·Annika Strandell
Aug 4, 2007·Journal of Assisted Reproduction and Genetics·John Rinehart
Nov 21, 2007·Human Reproduction·Annemiek W Nap, Johannes L H Evers
Jan 15, 2008·Archives of Gynecology and Obstetrics·Christiane KlingDieter Kabelitz
Aug 15, 2008·Human Reproduction Update·Scott M Nelson, Ian A Greer
Sep 4, 2008·Human Fertility : Journal of the British Fertility Society·Rachel CuttingUNKNOWN BFS and ACE

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Citations

Nov 26, 2013·Reproductive Biomedicine Online·Pedro N BarriIgnacio Rodriguez
Mar 4, 2014·Reproductive Biomedicine Online·Lukasz T PolanskiNicholas J Raine-Fenning
Jul 28, 2011·Women's Health·Corrado LodigianiEmanuele Levi Setti Paolo
Sep 2, 2011·Women's Health·Amir KupermanBenjamin Brenner
Jul 28, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Amal Shohayeb, Waleed El-Khayat
Jun 7, 2011·Journal of Reproductive Immunology·Michael K Bohlmann
Jan 26, 2011·Thrombosis Research·Scott M Nelson
Aug 21, 2013·The Cochrane Database of Systematic Reviews·Muhammad A AkhtarSiobhan Quenby
Mar 5, 2020·Clinical Case Reports·Magdy Mohamed AllamRasha Noureldin M Saleh
Apr 9, 2017·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Nikolaos VlachadisEmmanuel Economou

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