Management of a child with renal artery stenosis and homozygous factor V Leiden mutation

Journal of Pediatric Surgery
Anjali A Sharathkumar, James C Stanley

Abstract

Presence of factor V Leiden mutation is a known risk factor for thrombosis. It contributes for premature occlusion of vascular anastomosis. This report describes the intraoperative and postoperative anticoagulation management of a girl with homozygous factor V Leiden mutation and renal artery stenosis after her renovascular reconstruction surgery. This report suggests that postoperative anticoagulation may be helpful for the successful maturation of vascular anastomoses in children with underlying acquired or hereditary risk factors for thrombosis including factor V Leiden mutation.

References

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Mar 5, 2004·Annals of Internal Medicine·Klaus JuulBørge G Nordestgaard
Oct 13, 2006·Pediatric Transplantation·Birgitta KranzPeter F Hoyer
Oct 24, 2006·Journal of Vascular Surgery·James C StanleyThomas W Wakefield
Dec 16, 2006·Seminars in Thrombosis and Hemostasis·Valerio De StefanoGiuseppe Leone
Apr 17, 2007·Seminars in Hematology·Philippe de Moerloose, Françoise Boehlen

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