Management of acromegaly in pregnant woman

Annales d'endocrinologie
L Ben Salem HachmiC Ben Slama

Abstract

Pregnancy in acromegalic patients is an infrequent event, due to perturbed gonadotroph function. On the other hand, pregnancy may cause an enlargement of the adenoma or an increase of growth hormone (GH) secretion. We report the case of a 26-year-old woman with a GH-secreting pituitary macroadenoma who was operated by transphenoidal approach. After surgery, she had a persistent acromegaly due to an intrasellar tumour. She was treated by lanreotide. After one year, the patient had married and became pregnant. Lanreotide was stopped when the diagnosis of pregnancy was established. The follow-up of this patient showed a progressive increase of IGF1 level during pregnancy without tumoral syndrome or visual troubles. No metabolic complication was detected. The patient went to term and gave birth to a healthy baby. In postpartum, the IGF1 level was normal, but the brain MRI revealed a 10mm intrasellar tumour. The pituitary adenoma was not significantly enlarged during pregnancy. Therefore, pregnancy doesn't influence acromegaly in young women well controlled by medical treatment.

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Citations

Nov 24, 2011·Endocrinology and Metabolism Clinics of North America·Soriaya MotivalaKalmon D Post
Aug 12, 2016·Obstetric Medicine·Angela AssalErin Keely
Mar 16, 2017·European Journal of Endocrinology·Julio AbuchamMonike L Dias
Jan 31, 2019·Expert Review of Endocrinology & Metabolism·Philippe ChansonPhilippe Caron
Sep 15, 2019·Clinical Endocrinology·Magaly VialonPhilippe J Caron
Jun 27, 2020·Anti-cancer Drugs·Giulia MeoniLorenzo Antonuzzo

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