PMID: 6990745May 1, 1980Paper

Management of acute asthma in childhood. A randomized evaluation of beta-adrenergic agents

American Journal of Diseases of Children
A L SchwartzF J Twarog

Abstract

We examined the efficacy of several beta-adrenergic agents commonly used to treat asthma and evaluated the optimum route of administration. Two hundred and sixty-nine persons aged 5 to 21 years who came to the emergency ward while suffering from acute asthma were treated with either (1) inhalation isoetharine hydrochloride or (2) subcutaneous epinephrine or terbutaline sulfate. Patients were evaluated using clinical scores and pulmonary function tests and were monitored for adverse side effects. Regardless of mode of therapy, the acute attack was either treated successfully, terminated in hospital admission, or required further therapy within 24 hours in a comparable number of patients. Adverse side effects were more common with terbutaline sulfate than with either epinephrine or isoetharine in the doses used. Thus, inhalation of beta-adrenergic agents is as effective as subcutaneous administration in the treatment of acute asthma in childhood.

Citations

Apr 2, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Christopher L CarrollCraig M Schramm
Jul 1, 1982·The Journal of the American Dental Association·E T Geist, J H Diaz
Aug 1, 1989·The Journal of Allergy and Clinical Immunology·E R McFadden
Mar 1, 1993·The American Journal of Emergency Medicine·L G YamamotoC M Uechi
Mar 1, 1992·British Journal of Obstetrics and Gynaecology·P J Brunskill
Jan 1, 1982·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·R L Siegel, F J Twarog
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Andrew H TraversBrian H Rowe
Jan 1, 1983·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·R S Zeiger
Jan 1, 1992·The Annals of Pharmacotherapy·H W Kelly, S Murphy
Jul 1, 1985·Drug Intelligence & Clinical Pharmacy·R M ElenbaasM J Singsank

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