PMID: 526463Dec 1, 1979

Management of acute closed-angle glaucoma with miotics and timolol

The British Journal of Ophthalmology
P J AiraksinenE A Jaanio


The hypotensive effect of intramuscular or intravenous acetazolamide with frequent instillation of 2% or 4% pilocarpine in polyvinyl alcohol, or with single drops of pilocarpine in polyvinyl alcohol or oily vehicles, and the hypotensive effect of topical timolol alone and together with pilocarpine was investigated in the treatment of acute closed-angle glaucoma in 75 patients (81 eyes). The results showed that there was no marked difference in the hypotensive effect whether pilocarpine was used frequently or in a single dose, in different concentrations, or in different vehicles after acetazolamide. Topical timolol alone was not effective enough to control the intraocular pressure in acute closed-angle glaucoma, but a good hypotensive effect was seen when topical timolol was followed by pilocarpine. It is concluded that 1 drop of pilocarpine 3 hours after intravenous or intramuscular acetazolamide or after topical timolol may be sufficient to terminate an acute attack. Topical timolol may serve as a valuable alternative when systemic medication is contraindicated.


Oct 1, 1978·Acta Ophthalmologica·E Kerty, I Hørven
Apr 1, 1977·Archives of Ophthalmology·T J Zimmerman, H E Kaufman
May 1, 1978·The British Journal of Ophthalmology·K WettrellM Pandolfi
Jul 1, 1978·American Journal of Ophthalmology·W P BogerD Pavan-Langston
Nov 1, 1978·Archives of Ophthalmology·R L Coakes, R F Brubaker
May 1, 1978·The British Journal of Ophthalmology·S A SmithR Lazare
Aug 1, 1978·Journal of Pharmaceutical Sciences·L M DeSantis, R D Schoenwald
Apr 1, 1975·The British Journal of Ophthalmology·F Ganias, R Mapstone
Jul 1, 1974·The British Journal of Ophthalmology·J S Hillman
Jan 1, 1972·Archives of Ophthalmology·P C Rutkowski, H S Thompson
Jan 1, 1972·Archives of Ophthalmology·P C Rutkowski, H S Thompson
Jan 1, 1965·American Journal of Ophthalmology·E EPSTEIN, I KAUFMAN


Apr 18, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Xiuming JinJia Qu
Nov 26, 1999·Australian and New Zealand Journal of Ophthalmology·R Cooper
Mar 8, 1980·British Medical Journal·H Ellis
Aug 1, 1982·American Journal of Ophthalmology·R Ritch
Oct 30, 2004·Seminars in Ophthalmology·Sek-Tien HohPaul T K Chew
Aug 23, 2005·Ophthalmology·Tetsuya YamamotoTajimi Study Group, Japan Glaucoma Society

Related Concepts

Acetazolamide Sodium, (Sterile)
Acute Disease
Drug Administration Schedule
Physiologic Intraocular Pressure
Ophthalmic Solution

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