Management of Acute Complications of Targeted Therapy in Patients With Cancer: A Review of Cases Managed in ICU

Journal of Intensive Care Medicine
Aureliano PistoneAnne-Pascale Meert

Abstract

Targeted therapies, molecules in full expansion, are not free of side effects that can lead patients to intensive care. We performed an extensive review of the published evidence and propose a management strategy for acute complications of targeted therapy in critically ill patients with cancer. The literature search was performed in August 2017 using the Ovid Medline system by a scientific librarian and physicians. We made a review of cases admitted in intensive care unit (ICU) and a review of toxicities of grades greater or equal to 3. Our search selected 59 articles. The main cardiovascular side effects requiring ICU are heart failure, which is generally reversible, severe hypertension, thrombotic and ischemic events, and rhythm disturbances. The main pulmonary side effects are interstitial lung disease essentially caused by crizotinib, respiratory infections, pneumothorax, and alveolar hemorrhage. The main gastrointestinal side effects are fulminant hepatitis that may be fatal, colitis that may be complicated by hemorrhage, and perforation. The main neurological side effect is posterior reversible encephalopathy syndrome essentially caused by bevacizumab. The main other side effects are Steven-Johnson syndrome, necrotizing ...Continue Reading

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Citations

Feb 13, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bin HuangJiumao Lin

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Methods Mentioned

BETA
biopsy

Software Mentioned

OvidSP
Ovid Medline
Ovid

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