Management of anaemia: a critical and systematic review of the cost effectiveness of erythropoiesis-stimulating agents

PharmacoEconomics
Mei Sheng DuhPaul E Greenberg

Abstract

Erythropoiesis-stimulating agents (ESAs) are genetically engineered forms of erythropoietin that are used in the treatment of anaemia. Their successful use in the treatment of anaemia associated with renal disease, cancer and other diseases, as well as the development of multiple agents, has increased the visibility of these agents in the clinical and health economics literature. The circumstances under which the use of ESAs is cost effective, or indeed, whether it is cost effective, is of central concern for clinicians and payers who must make informed decisions regarding the management of these costly resources. Much of the recent literature on ESAs in the treatment of anaemia associated with chronic kidney disease and cancer, the two major therapeutic areas for ESA treatment, has focused on comparisons between individual ESAs, particularly epoetin alfa and darbepoetin alfa. While there have been some studies of cost effectiveness, many studies in these treatment areas have employed a cost-minimization approach and have relied on published prices rather than actual market prices. In general, this review of the literature suggests a cost advantage for epoetin alfa relative to darbepoetin alfa in the treatment of anaemia in ren...Continue Reading

References

Nov 30, 1999·Journal of the American Society of Nephrology : JASN·I C MacdougallJ Egrie
Sep 5, 2001·Journal of Paediatrics and Child Health·C L YeoL Y Ho
Mar 18, 2004·Current Medical Research and Opinion·Anthony MorrealeMonica Schaefer
Jul 22, 2004·Current Medical Research and Opinion·Gilbert Deray
Sep 29, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas E WitzigRoscoe F Morton
Nov 5, 2004·PharmacoEconomics·Monia Marchetti, Giovanni Barosi
Dec 21, 2004·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·E RemákM Zagari
Oct 4, 2005·Current Medical Research and Opinion·Tami L MarkCatherine Tak Piech
Dec 1, 2005·Journal of the National Comprehensive Cancer Network : JNCCN·Susana M CamposJames Rosberg
Dec 8, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Eric J Kruep, Lorne E Basskin
May 20, 2006·Current Medical Research and Opinion·Frank J PapatheofanisCatherine Tak Piech
Aug 8, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Carlos LucasMaria Joao Pais
Oct 7, 2006·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Pierre CremieuxPatrick Lefebvre
Nov 17, 2006·The New England Journal of Medicine·Ajay K SinghUNKNOWN CHOIR Investigators
Nov 30, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Richard A Del RioMendel E Singer
Feb 22, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey Crawford
Aug 1, 2005·Expert Review of Pharmacoeconomics & Outcomes Research·Mei Sheng Duh, Tami L Mark

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Citations

Nov 19, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·François LüthiChristian Monnerat
Apr 24, 2010·Clinical Journal of the American Society of Nephrology : CJASN·David Goldsmith
May 30, 2012·Cadernos de saúde pública·Thaís Caroline GurgelEli Iola Gurgel Andrade
Jul 23, 2013·Cost Effectiveness and Resource Allocation : C/E·Eleftheria NikolaidiMary Geitona
Dec 6, 2008·Transfusion Medicine Reviews·Brian Custer, Jeffrey S Hoch

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