Management of anti-HBc-positive patients with rheumatic diseases treated with disease-modifying antirheumatic drugs-a single-center analysis of 2054 patients

Clinical Rheumatology
Eva C SchwaneckAndreas Geier

Abstract

Hepatitis B virus (HBV) reactivation is a common complication of immunosuppressive treatment in high prevalence countries. Biological disease-modifying antirheumatic drugs (bDMARDs) cause this adverse event more often than conventional immunosuppressants. The incidence of HBV reactivation during treatment for rheumatic diseases in Germany is unclear. Furthermore, it remains open how to treat and monitor patients at risk during immunosuppressive therapy with bDMARDs. We examined 2054 patients from a German tertiary rheumatology center in order to analyze the prevalence of HBc-antibody-positivity and the incidence of HBV reactivation in German rheumatology patients treated with immunosuppressants. Of 1317 patients treated with bDMARDs and 737 conventional synthetic DMARD (csDMARDs) patients between 2008 and 2017, 86 had a history of HBV infection (anti-HBc positive). Only two patients were suffering from chronic infection (HBsAg positive). Three patients were treated pre-emptively with entecavir, and eight patients after HBV DNA reappearance. No liver failure occurred due to HBV reactivation. Compared to anti-HBc-positive patients without reactivation, the reactivation group included more patients exposed to three or more classes...Continue Reading

References

Dec 31, 2003·Lancet·Ching Lung LaiThierry Poynard
Oct 28, 2006·Annals of the Rheumatic Diseases·J S SmolenUNKNOWN Working Group on the Rituximab Consensus Statement
Aug 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna S F Lok, Brian J McMahon
Jun 26, 2010·Gut·C LorasUNKNOWN GETECCU (Grupo Español de Enfermedades de Crohn y Colitis Ulcerosa) Group
Mar 8, 2011·Annals of the Rheumatic Diseases·Maya H BuchUNKNOWN Rituximab Consensus Expert Committee
Jul 13, 2011·Zeitschrift für Gastroenterologie·M CornbergUNKNOWN AWMF
Jun 24, 2014·Lancet·Christian TrépoAnna Lok
Aug 2, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Mike van der HaveUNKNOWN Dutch Initiative on Crohn and Colitis (ICC)
Jan 24, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michele BaroneGiovanni Lapadula
Aug 2, 2015·Lancet·Jennifer H MacLachlanBenjamin C Cowie
Nov 8, 2015·Arthritis & Rheumatology·Jasvinder A SinghTimothy McAlindon
May 18, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stevan A Gonzalez, Robert P Perrillo
Oct 7, 2016·The Open Rheumatology Journal·Martin FeuchtenbergerMichael Rupert Kraus
Apr 22, 2017·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver
Jan 10, 2018·BMC Gastroenterology·Chien-Yuan ChenWang-Huei Sheng

❮ Previous
Next ❯

Citations

Jan 17, 2020·Journal of Clinical Medicine·Florian MorettoLionel Piroth
Mar 25, 2020·Therapeutic Advances in Musculoskeletal Disease·Christos KoutsianasDimitrios Vassilopoulos
Feb 1, 2020·Gut·Grace Elizabeth Dolman, Patrick T F Kennedy
Sep 11, 2021·International Journal of Rheumatic Diseases·Sz-Tsan WangNing-Sheng Lai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.