Management of anticoagulation associated reproductive tract bleeding in adolescent and young adult females - Results of a multinational survey.

Thrombosis Research
Madhvi RajpurkarPeter Kouides

Abstract

Reproductive tract bleeding (RTB) is an important outcome in menstruating females on anticoagulant therapy (AC). The diagnosis and management of AC-RTB in adolescent and young adult (AYA) females is unknown. The aim of this study was to survey the contemporary patterns of diagnosis and management of AC-RTB in AYA females. SurveyMonkey® questions were sent to members of 1) Pediatric and Neonatal Thrombosis Hemostasis Subcommittee and Women's Health Subcommittee of the International Society on Thrombosis and Haemostasis and 2) Hemostasis and Thrombosis Research Society. Results are reported using descriptive statistics. Response rate was 33% (251 out of 753). AC-RTB was infrequently reported. Menstrual history was not routinely reviewed prior to initiation of AC. Respondents indicated a differential risk of AC-RTB, most frequently with Rivaroxaban. Respondents continued hormonal therapy (HT) if an AYA female was on it at the start of AC. When AC-RTB occurred, management strategies were variable with initiation of HT or antifibrinolytic therapy being the most frequent. The timing of AC-RTB after the thrombotic event influenced the respondents' choice of therapy. Differences were seen in the management strategies between US and non...Continue Reading

References

Jun 11, 2011·Journal of Paediatrics and Child Health·Lyndal J PeakeAndrew D Kennedy
Mar 1, 2012·American Journal of Hematology·John A Heit
Jul 28, 2015·British Journal of Haematology·Melanie FerreiraRoopen Arya
Mar 8, 2016·The Journal of Pediatrics·Christine A SabapathyVicky Tagalakis
May 23, 2016·Thrombosis Research·Ayesha Zia, Madhvi Rajpurkar
Nov 3, 2017·Blood·Kochawan BoonyawatShannon M Bates
Dec 24, 2017·Journal of Pediatric and Adolescent Gynecology·Heather SoniLakshmi V Srivaths
Feb 28, 2018·Academic Medicine : Journal of the Association of American Medical Colleges·Anthony R ArtinoDavid P Sklar
Mar 30, 2018·Clinical Obstetrics and Gynecology·Andrew Rivara, Andra H James
Jul 6, 2018·Journal of Thrombosis and Haemostasis : JTH·M V HuismanF A Klok
Sep 13, 2018·Haemophilia : the Official Journal of the World Federation of Hemophilia·Ayesha ZiaSarah H O'Brien
Mar 16, 2019·European Journal of Internal Medicine·Beatriz LacruzUNKNOWN RIETE Investigators
Aug 20, 2019·The Lancet. Haematology·Anjali A Sharathkumar
Sep 4, 2019·Thrombosis Research·Frederikus A Klok, Stefano Barco
Dec 6, 2019·Blood·Leonardo R BrandãoUNKNOWN DIVERSITY Study Investigators
Dec 5, 2020·Hematology·Bethany Samuelson Bannow

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