Management of antiphospholipid antibody syndrome: a systematic review

JAMA : the Journal of the American Medical Association
Wendy LimJohn W Eikelboom

Abstract

Antiphospholipid antibodies are autoantibodies directed against proteins that bind to phospholipid. Antiphospholipid antibody syndrome (APS) refers to the association between antiphospholipid antibodies and thrombosis risk or pregnancy morbidity. Patients with APS may be at increased risk of recurrent arterial or venous thrombosis or pregnancy loss. To systematically review the evidence for treatment of thrombosis risk in patients with antiphospholipid antibodies or APS. Search of MEDLINE (1966 to November 2005) and Cochrane Library electronic databases (2005) and reference lists for randomized trials, meta-analyses of randomized trials, and prospective cohort studies of the treatment of thrombosis risk in patients with antiphospholipid antibodies or APS. Studies were selected on the basis of clinical relevance. Among patients with antiphospholipid antibodies, the absolute risk of developing new thrombosis is low (<1% per year) in otherwise healthy patients without prior thrombotic events, may be moderately increased (up to 10% per year) in women with recurrent fetal loss without prior thrombosis, and is highest (>10% in the first year) in patients with a history of venous thrombosis who have discontinued anticoagulant drugs wi...Continue Reading

Citations

Jan 23, 2014·Current Rheumatology Reports·Cecilia NalliAngela Tincani
Jan 28, 2014·Journal of Autoimmunity·Jose A Gómez-Puerta, Ricard Cervera
Dec 21, 2013·Current Rheumatology Reports·Guillermo J Pons-Estel, Ricard Cervera
Jan 28, 2014·Acta neurologica Belgica·Ch De MaeseneireM Gille
Jun 17, 2008·Journal des maladies vasculaires·C Le HelloJ Constans
Mar 26, 2011·Rheumatology International·Elisa Watanabe CamargoJozélio Freire de Carvalho
Feb 19, 2011·Stroke Research and Treatment·Kay W P NgVijay K Sharma
Oct 1, 2011·Neurology Research International·Bharath WootlaMoses Rodriguez
Jul 1, 2006·Women's Health·Ana M Arango, John D Reveille
Mar 2, 2010·Women's Health·Doruk Erkan
Jan 28, 2009·Current Rheumatology Reports·David D'Cruz
Apr 29, 2010·Current Rheumatology Reports·Mark Crowther, Mark A Crowther
Nov 24, 2011·Current Rheumatology Reports·Kessarin PanichpisalSteven R Levine
Sep 16, 2010·Nature Reviews. Cardiology·Josien van EsHarry R Büller
Nov 19, 2008·Journal of Autoimmune Diseases·Ana G Fonseca, David P D'Cruz
Oct 13, 2009·Cardiovascular Ultrasound·Christos PliakosPavlos Nikolaidis
Nov 14, 2012·Nature Reviews. Rheumatology·Berthold Hoppe, Thomas Dörner
Aug 5, 2006·Current Opinion in Hematology·Paolo Simioni
Oct 6, 2007·Clinical Reviews in Allergy & Immunology·Eyal Reinstein, Yehuda Shoenfeld
Jan 12, 2011·Clinical Reviews in Allergy & Immunology·Benjamín Rubio-JuradoArnulfo Nava
Dec 17, 2008·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Susanna TanChin Lee
Jul 25, 2009·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·F BubackK Scharffetter-Kochanek
Jun 18, 2011·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Lasse PihlstrømEmilia Kerty
Apr 7, 2012·International Anesthesiology Clinics·Benjamin M Sherman, Kenneth L Haspel
Oct 2, 2007·Journal of Thrombosis and Thrombolysis·Wendy A Leong
Jul 7, 2009·Journal of Thrombosis and Thrombolysis·M Houman FekrazadDavid Garcia
Nov 18, 2008·The Journal of Perinatal & Neonatal Nursing·Susan MathewLene Symes
Sep 9, 2010·Rheumatology·Alastair L HepburnJustin C Mason
Nov 4, 2006·Clinical Obstetrics and Gynecology·D Ware Branch, Alexandra Grosvenor Eller
Sep 10, 2008·Nature Clinical Practice. Rheumatology·Andrea Doria, Chiara Briani
Mar 3, 2009·Nature Clinical Practice. Rheumatology·Doruk Erkan, Michael D Lockshin
Jul 1, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bassam AlchiDavid Jayne
Feb 3, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lidia GhisdalDaniel Abramowicz
Jun 16, 2012·Human Reproduction Update·Christine A ClarkKaren A Spitzer
Mar 15, 2008·Critical Pathways in Cardiology·Gregory Piazza, Samuel Z Goldhaber
Aug 9, 2008·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M RehakP Wiedemann
Jun 6, 2009·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·J HarderI Lanzl
Nov 21, 2007·Hematology·Jacob H Rand

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