Management of Antiphospholipid Syndrome

Biomedicines
Amine Ghembaza, David Saadoun

Abstract

Antiphospholipid syndrome (APS), is an acquired autoimmune disorder characterised by thrombosis, pregnancy morbidity, and the presence of antiphospholipid antibodies (aPL). Although venous thromboembolism is the most common manifestation, thrombotic events in APS may also occur in virtually any vascular bed, with cerebral circulation being the arterial territory most commonly affected. As APS is a heterogeneous condition, its management should be tailored with a patient-centred approach based on individual risk assessment, which includes the aPL profile, concomitant auto-immune diseases, and traditional cardiovascular risk factors. Although literature data are conflicting regarding primary prophylaxis, there is some evidence indicating that antiplatelet agents may reduce the risk of a first thrombotic event in individuals with a high-risk profile. In patients with thrombotic APS, current evidence-based guidelines recommend lifelong vitamin K antagonists (VKAs), preferably warfarin. The optimal intensity of anticoagulation following arterial thrombosis remains controversial. Arterial thrombosis should be treated either with high-intensity warfarin at a target INR > 3.0, or low-dose aspirin (LDA) combined with moderate-intensity ...Continue Reading

References

Aug 15, 1992·Annals of Internal Medicine·M H Rosove, P M Brewer
Aug 2, 2003·Lupus·R A AshersonUNKNOWN Catastrophic Antiphospholipid Syndrome Registry Project Group
Sep 12, 2003·Current Rheumatology Reports·Ronald A Asherson, Ricard Cervera
Dec 4, 2003·Annals of the Rheumatic Diseases·G R V Hughes, M A Khamashta
Feb 6, 2004·JAMA : the Journal of the American Medical Association·Steven R LevineUNKNOWN APASS Investigators
Jun 30, 2005·Arthritis and Rheumatism·Silvia S PierangeliJane Salmon
Feb 18, 2006·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·E K KahwaR Wilks
Mar 2, 2006·JAMA : the Journal of the American Medical Association·Wendy LimJohn W Eikelboom
Jan 22, 2008·Hematology/oncology Clinics of North America·Rima M Dafer, José Biller
Aug 30, 2008·Blood·Bill GiannakopoulosSteven A Krilis
Feb 3, 2011·Annals of the Rheumatic Diseases·Amelia RuffattiUNKNOWN Antiphospholipid Syndrome Study Group of Italian Society of Rheumatology
Jan 15, 2013·Rheumatology·Savino SciasciaMaria Laura Bertolaccini
Jan 10, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B E LonzeR A Montgomery
Apr 2, 2014·British Journal of Haematology·Deepa Jayakody Arachchillage, Mike Greaves
Aug 15, 2014·Rheumatology·Savino SciasciaMaria Laura Bertolaccini
Oct 18, 2014·Journal of Perinatal Medicine·Katarina JeremicJelena Jeremic
Jan 27, 2015·Autoimmunity Reviews·Arsène MekinianUNKNOWN SNFMI and the European Forum on Antiphospholipid Antibodies
Oct 3, 2015·American Journal of Obstetrics and Gynecology·S SciasciaM J Cuadrado
Jul 28, 2016·The Journal of Clinical Investigation·Eleftheria LefkouGuillermina Girardi
Sep 19, 2016·Autoimmunity Reviews·Ignasi Rodríguez-PintóUNKNOWN CAPS Registry Project Group (European Forum on Antiphospholipid Antibodies)

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Citations

Aug 20, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Vito TotaStéphane Holbrechts

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Methods Mentioned

BETA
RAPS

Clinical Trials Mentioned

NCT03152058

Software Mentioned

EULAR
PROMISSE
APLASA

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

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