Management of autoimmune skin disorders in the elderly

Drugs & Aging
Wei Jing Loo, Nigel P Burrows

Abstract

Senescence of the skin immunological system may explain why the elderly population has an increased susceptibility to certain autoimmune skin disorders. These disorders are characterised by the production of either antibodies that react with host tissue or immune effector T cells that are autoreactive. Bullous pemphigoid is the most common autoimmune blistering disease in the elderly. Although oral corticosteroids are the best established therapy, high-potency topical corticosteroids are very useful as initial treatment and, in the elderly, should be used instead of oral prednisolone wherever possible. Pemphigus is a chronic blistering disease of which there are two main subtypes: vulgaris and foliaceous. Paraneoplastic pemphigus is a unique clinical, histological and immunologically distinct autoimmune mucocutaneous disease which tends to be relentlessly progressive. Lichen sclerosus presents specific complications and a small but definite increased risk of squamous cell carcinoma in elderly patients. It is important to be aware of practical issues such as the difficulty in applying topical corticosteroids, the mainstay treatment of this condition. Dermatomyositis is an autoimmune systemic disorder where the skin and muscles a...Continue Reading

References

Oct 28, 1978·British Medical Journal·J L BurtonR P Warin
Aug 1, 1992·Archives of Dermatology·T D Horn, G J Anhalt
Mar 1, 1989·Journal of the American Academy of Dermatology·W Westerhof
Mar 1, 1987·Journal of the American Academy of Dermatology·W AbererK Wolff
Oct 1, 1982·Journal of the American Academy of Dermatology·B J FoxR F Findlay
Aug 1, 1980·Journal of the American Academy of Dermatology·J P Callen
Oct 1, 1981·The Journal of Clinical Investigation·G J AnhaltL A Diaz
Aug 1, 1982·The Journal of Investigative Dermatology·B A GilchrestN A Soter
Mar 1, 1980·Archives of Dermatology·R E Fitzpatrick, V D Newcomer
Aug 1, 1995·Archives of Dermatology·D ZillikensE B Bröcker
Jun 1, 1994·Archives of Dermatology·D P FivensonD Mutasim
Jul 1, 1995·Clinical and Experimental Dermatology·S C Huilgol, M M Black
Apr 1, 1996·Journal of the American Academy of Dermatology·F BouscaratS Belaich
Dec 1, 1995·International Journal of Dermatology·J S PasrichaM Chandra
May 1, 1996·The British Journal of Dermatology·T ItohT Horio
Oct 24, 1997·Archives of Dermatology·C SunderkötterT A Luger
Jan 29, 1999·Archives of Dermatology·A H Enk, J Knop
May 13, 1999·Journal of the American Academy of Dermatology·J D HeilbornE Stephansson
Jun 3, 1999·The British Journal of Dermatology·A M FarrellF Wojnarowska
Oct 16, 1999·Annals of Internal Medicine·P H BrionK C Kalunian
Mar 22, 2000·Journal of the American Academy of Dermatology·S M TavadiaD N Sauder
Apr 12, 2000·International Journal of Dermatology·C A EganJ J Zone
Dec 21, 2000·The British Journal of Dermatology·E K DerrickS M Neill
Feb 1, 2002·The New England Journal of Medicine·Pascal JolyUNKNOWN Bullous Diseases French Study Group
Jun 20, 2002·Archives of Dermatology·Agnès SparsaJean-Marie Bonnetblanc
Nov 28, 2002·International Journal of Dermatology·Nobuo WakataMasao Kinoshita
Jul 18, 2003·Lancet·Noritaka OyamaJohn A McGrath

❮ Previous
Next ❯

Citations

Jan 20, 2012·Journal of Lower Genital Tract Disease·Gary VentoliniMichael L Galloway
Feb 19, 2009·American Journal of Clinical Dermatology·Miranda A FarageHoward I Maibach
Aug 15, 2015·Annals of Dermatology·Yong Hyun JangDo Won Kim
Dec 15, 2010·Clinics in Dermatology·Sueli Coelho da Silva CarneiroMarcia Ramos-e-Silva
Feb 10, 2009·International Journal of Dermatology·Virendra N Sehgal, Govind Srivastava
Oct 23, 2016·Drugs & Aging·Minhee KimDédée F Murrell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

The Journal of Dermatologic Surgery and Oncology
S Asken
Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
G D Monheit
© 2021 Meta ULC. All rights reserved