Management of bilateral Wilms tumours

Pediatric Surgery International
Alastair J W MillarAlan Davidson

Abstract

Wilms tumour is named after Max Wilms. It is an embryonal tumour derived from the metanephros. It is the commonest childhood renal tumour and the third commonest paediatric malignancy. Synchronous bilateral Wilms tumours (BWT) represent 4-7% of all Wilms tumours (WT) and present at a younger age than unilateral Wilms tumours. At least 10% of synchronous BWTs have unfavourable histology, and up to 22% are associated with genitourinary abnormalities, aniridia, WAGR syndrome, Denys-Drash syndrome, hemihypertrophy, or one of the other overgrowth syndromes. The long-term disease-free survival rate for patients with unilateral WT is approaching 90%, and is around 70% for those with metastatic disease. For both synchronous and metachronous Wilms tumours the prognosis is less favourable with reported cure rates approaching 80% in the best centres and lower in resource poor settings. There is potential for a reduced quality of life due to renal insufficiency and the possible need for renal transplantation. The major clinical challenge in BWTs is preservation of functioning renal tissue using nephron-sparing surgical techniques, while achieving cure with minimum therapy-related morbidity. Mortality is generally associated with progressiv...Continue Reading

References

Mar 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M J CoppesV S Blanchette
Aug 1, 1991·The Journal of Urology·B T MontgomeryG J D'Angio
Oct 1, 1987·The Journal of Urology·M L BluteG J D'Angio
Jan 1, 1993·Medical and Pediatric Oncology·J B Beckwith
Feb 1, 1996·Medical and Pediatric Oncology·M L RitcheyN E Breslow
Apr 1, 1996·Medical and Pediatric Oncology·A B Jonge Poerink-StockschladerK Hählen
Jun 26, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C RudinR S Trompeter
Sep 14, 2000·The Urologic Clinics of North America·H L Neville, M L Ritchey
May 24, 2001·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·K PayaA Zoubek
Mar 21, 2002·Journal of Pediatric Hematology/oncology·John AndersonJon Pritchard
Apr 28, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A WeirichP A Voûte
Aug 6, 2005·Journal of Pediatric Surgery·Alastair J W MillarFarieda Desai
Dec 13, 2005·Pediatric Blood & Cancer·Alan DavidsonAlastair Millar
Mar 29, 2006·Journal of Pediatric Surgery·Robert C ShambergerMichael L Ritchey
May 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey S DomeDaniel M Green
Oct 3, 2006·Journal of Pediatric Surgery·Thomas E HamiltonRobert C Shamberger
Jul 11, 2009·Expert Review of Anticancer Therapy·Peter F Ehrlich
Apr 12, 2011·African Journal of Paediatric Surgery : AJPS·A J W MillarFarieda Desai
Feb 16, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Ilona A DekkersMarry M van den Heuvel-Eibrink
May 9, 2013·Journal of Pediatric Hematology/oncology·Sharon G CoxAlastair J W Millar
Jan 21, 2014·Journal of Pediatric Surgery·Kathleen KieranAndrew M Davidoff
Aug 27, 2014·Pediatric Blood & Cancer·Jim C H WildeJan Godzinski
Sep 3, 2014·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·Irene Isabel P LimTodd E Heaton
Jan 31, 2015·Pediatric Surgery International·Kathleen Kieran, Andrew M Davidoff
Feb 2, 2015·Journal of Pediatric Surgery·John Raffensperger
Jul 1, 2015·Urologic Oncology·Kathleen Kieran, Peter F Ehrlich
Aug 10, 2015·Urologic Oncology·Rand N Wilcox Vanden BergJonathan C Routh

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Citations

Jul 20, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jun WangRugang Lu
Nov 9, 2019·Pediatric Surgery International·Sharon CoxAlastair J W Millar
Jan 15, 2020·Seminars in Pediatric Surgery·Melissa PerrinoJames I Geller

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