Management of bleeding irregularities among etonogestrel implant users: Is combined oral contraceptives pills or nonsteroidal anti-inflammatory drugs the better option?

The Journal of Obstetrics and Gynaecology Research
Siti N UpawiShuhaila Ahmad

Abstract

This study is to evaluate whether unacceptable bleeding among the etonogestrel implant user could be better alleviated using combined oral contraceptive pills (COCP) or nonsteroidal anti-inflammation drugs (NSAID). This is a prospective randomized study for evaluation of 84 etonogestrel implant (Implanon) users with prolonged or frequent bleeding. They were assigned to either receiving a COCP containing 20 mcg ethinyl estradiol/150 mg desogestrel for two continuous cycle or NSAID; mefenamic acid 500 mg TDS for 5 days, 21 days apart for two cycles. Bleeding pattern during the treatment was recorded and analyzed. A total of 32 women (76.2%) in COCP group and 15 women (35.7%) in NSAID group stop bleeding within 7 days after the initiation of treatment which was statistically significant (P < 0.05). The mean duration of bleeding and spotting days in women treated with COCP was significantly lesser compared to NSAID group (7.29 ± 3.16 vs 10.57 ± 4.14 days (P < 0.05). We conclude that COCP is more efficient compared to NSAID in managing bleeding irregularities among etonogestrel implant users.

References

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Citations

Jul 22, 2020·Current Opinion in Pediatrics·Alexandra J EdwardsSarah Pitts
Sep 6, 2020·Current Opinion in Obstetrics & Gynecology·Andrea Henkel, Lisa M Goldthwaite
Jul 3, 2021·Pharmaceuticals·Morena Luigia RoccaCostantino Di Carlo

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