Management of bleeding irregularities among etonogestrel implant users: Is combined oral contraceptives pills or nonsteroidal anti-inflammatory drugs the better option?

The Journal of Obstetrics and Gynaecology Research
Siti N UpawiShuhaila Ahmad


This study is to evaluate whether unacceptable bleeding among the etonogestrel implant user could be better alleviated using combined oral contraceptive pills (COCP) or nonsteroidal anti-inflammation drugs (NSAID). This is a prospective randomized study for evaluation of 84 etonogestrel implant (Implanon) users with prolonged or frequent bleeding. They were assigned to either receiving a COCP containing 20 mcg ethinyl estradiol/150 mg desogestrel for two continuous cycle or NSAID; mefenamic acid 500 mg TDS for 5 days, 21 days apart for two cycles. Bleeding pattern during the treatment was recorded and analyzed. A total of 32 women (76.2%) in COCP group and 15 women (35.7%) in NSAID group stop bleeding within 7 days after the initiation of treatment which was statistically significant (P < 0.05). The mean duration of bleeding and spotting days in women treated with COCP was significantly lesser compared to NSAID group (7.29 ± 3.16 vs 10.57 ± 4.14 days (P < 0.05). We conclude that COCP is more efficient compared to NSAID in managing bleeding irregularities among etonogestrel implant users.


Oct 1, 1994·Human Reproduction·I Sivin
Mar 1, 1996·American Journal of Obstetrics and Gynecology·F Alvarez-SanchezA Faundes
Oct 1, 1996·Human Reproduction·J WitjaksonoP A Rogers
Sep 29, 2004·Contraception·Pisit Tantiwattanakul, Surasak Taneepanichskul
Aug 9, 2008·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Diana MansourIan S Fraser
Nov 26, 2015·Obstetrics and Gynecology Clinics of North America·EmmaKate Friedlander, Bliss Kaneshiro
Jul 16, 2016·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Melody Y HouMitchell D Creinin
Aug 22, 2018·Obstetrics and Gynecology·Rachel E ZiglerColleen McNicholas

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Jul 22, 2020·Current Opinion in Pediatrics·Alexandra J EdwardsSarah Pitts
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