Sep 1, 1977

Management of carcinoma in situ of the cervix

American Journal of Obstetrics and Gynecology
M L SprangC T Boraca

Abstract

Sixty-eight patients with in situ and seven patients with microinvasive cervical carcinoma were reviewed. Thirty per cent of the patients with carcinoma in situ were 30 years old and under. The mean age for carcinoma in situ was 37.8 years; for microinvasion, 42.6 years; and for postconization residual carcinoma, 48.5 years. Forty per cent of the patients were para 0 or 1. There was a 13 per cent incidence of postconization complications. The incidence of residual carcinoma in 58 patients who underwent conization and subsequent hysterectomy was only 10.3 per cent. The residual carcinoma was present high in the endocervical canal of the hysterectomy specimen. None of the patients with microinvasion had residual carcinoma. A positive correlation was found between the anatomic extent of the lesion on the conization specimen and the incidence of residual carcinoma. We conclude that conization and careful follow-up frequently are effective therapy for treating cervical carcinoma in situ, thereby reducing the incidence of hysterectomy.

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Hysterectomy
Biopsy
Carcinoma
Neoplasm, Residual
Uterine Cervicitis
Intraepithelial Neoplasia
Cervix Carcinoma

About this Paper

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.

IGA Glomerulonephritis

IgA glomerulonephritis is a chronic form of glomerulonephritis characterized by deposits of predominantly Iimmunoglobin A in the mesangial area. Discover the latest research on IgA glomerulonephritis here.

Cryogenic Electron Microscopy

Cryogenic electron microscopy (Cryo-EM) allows the determination of biological macromolecules and their assemblies at a near-atomic resolution. Here is the latest research.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

LRRK2 & Immunity During Infection

Mutations in the LRRK2 gene are a risk-factor for developing Parkinson’s disease. However, LRRK2 has been shown to function as a central regulator of vesicular trafficking, infection, immunity, and inflammation. Here is the latest research on the role of this kinase on immunity during infection.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Meningococcal Myelitis

Meningococcal myelitis is characterized by inflammation and myelin damage to the meninges and spinal cord. Discover the latest research on meningococcal myelitis here.

Alzheimer's Disease: MS4A

Variants within membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease by recent genome-wide association studies. Here is the latest research.