Management of children with high-risk Hodgkin lymphoma

British Journal of Haematology
Kara M Kelly

Abstract

Most children and adolescents with newly diagnosed high-risk Hodgkin lymphoma (HL) will achieve remission and cure with conventional chemotherapy with or without radiation therapy. However, these therapies can lead to long-term side effects. Therapy is titrated on the basis of risk group stratification using clinical prognostic factors and, in most cases, then refined through assessment of interim or end of chemotherapy response, primarily using functional imaging with fluorodeoxyglucose positron emission tomography. No study has clearly demonstrated the factors that are sufficient in identifying the patients at highest risk for relapse that may benefit from therapy intensification. This review summarizes recent clinical trials in paediatric high-risk HL, along with key findings from studies in adults with high-risk HL that are applicable to the paediatric population. New directions in prognostic classification and targeted therapies are reviewed. Considerations for clinical practice at the current time outside the clinical trial setting are provided.

References

Nov 20, 1998·The New England Journal of Medicine·Dirk Hasenclever, Volker Diehl
Nov 30, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G SchellongE-W Schwarze
Jun 1, 2000·Leukemia & Lymphoma·J Teruya-FeldsteinElaine S Jaffe
Jul 25, 2000·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·L J Johnston, Sandra J Horning
May 31, 2002·Blood·Brian F Skinnider, Tak W Mak
Sep 14, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James B NachmanChildren's Cancer Group
May 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ron S SmithSarah S Donaldson
Jun 13, 2003·The New England Journal of Medicine·Volker DiehlGerman Hodgkin's Lymphoma Study Group
Jun 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Massimo FedericoEBMT/GISL/ANZLG/SFGM/GELA Intergroup HD01 Trial
Dec 6, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S LaskarK A Dinshaw
Jun 2, 2004·Pediatric Blood & Cancer·Friederike G A J Hakvoort-CammelKarel Hählen
Nov 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Melissa M HudsonHoward J Weinstein
Dec 16, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A JostingAndreas Engert
Sep 15, 2005·Pediatric Blood & Cancer·Laxman S AryaTribhuvan S Vats
Jan 24, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D ChesonInternational Harmonization Project on Lymphoma
Feb 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cameron K TebbiCindy L Schwartz
Oct 16, 2007·International Journal of Cancer. Journal International Du Cancer·Donatella AldinucciAlfonso Colombatti
Oct 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maryam FouladiWayne L Furman
Feb 16, 2008·British Journal of Haematology·Marijke NiensAnke van den Berg
Dec 17, 2008·Nature Reviews. Cancer·Ralf Küppers
Jan 7, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Massimo FedericoHD2000 Gruppo Italiano per lo Studio dei Linfomi Trial
Aug 26, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andreas EngertMarkus Löffler
Sep 10, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter J HoskinPeter W M Johnson
Feb 4, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maureen M O'BrienMichael P Link
Mar 12, 2010·The New England Journal of Medicine·Christian SteidlRandy D Gascoyne
Mar 17, 2010·American Journal of Hematology·Patrick B JohnstonThomas E Witzig
May 12, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jennifer LevineCatharyn J Stern
Jun 18, 2010·Blood·Zhen WengJunling Liu
Jul 14, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christine Mauz-KörholzDieter Körholz
Aug 4, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul L NguyenMassimo Loda
Aug 21, 2010·Blood·Aleksandra RizoJan Jacob Schuringa
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christian SteidlRandy D Gascoyne
Jul 22, 2011·The New England Journal of Medicine·Simonetta VivianiIntergruppo Italiano Linfomi

Related Concepts

Clinical Trials
Combined Modality Therapy
Hodgkin Lymphoma, Lymphocyte Depletion
Remission Induction
Clinical Trials
Diagnostic Imaging
Hodgkin Disease
Positron-Emission Tomography
Fluorodeoxyglucose F18
Evaluation

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Computational Methods for Protein Structures

Computational methods employing machine learning algorithms are powerful tools that can be used to predict the effect of mutations on protein structure. This is important in neurodegenerative disorders, where some mutations can cause the formation of toxic protein aggregations. This feed follows the latests insights into the relationships between mutation and protein structure leading to better understanding of disease.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.