Management of CIN1

Journal de gynécologie, obstétrique et biologie de la reproduction
R Rouzier

Abstract

A cervical intraepithelial neoplasia grade 1 (CIN1) is a lesion of basal cells consisting in an architecture disorganization and cytological atypia limited to the lower third of the cervical epithelium. It is considered as a precancerous lesion uterine cervix carcinoma while they spontaneously regress in more than 60% of cases in two years. The problems related to the management of CIN1 as defined by the recommendations established in 2002 are the over-treatment and the great variability of clinical practices. Moreover, the potential of new tests has been investigated since 2002. To establish these new recommendations, the medline database has been consulted and the references essentially published between 2001 and May 2007 have been investigated. Publications were selected and classified according to their level of evidence (LE) in order to establish the grade of recommendations. One of the problems encountered when facing a CIN1 is to misdiagnose a more severe lesion firstly because of the intra- and interobserver variability and secondly because the colposcopy-directed biopsy is not mandatorily representative of the more severe lesion. Nevertheless, because the risk of cancer is extremely low, a conization is not necessary i...Continue Reading

References

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Mar 23, 2001·JAMA : the Journal of the American Medical Association·M H StolerUNKNOWN Atypical Squamous Cells of Undetermined Significance-Low-grade Squamous Intraepithelial Lesion Triage Study (ALTS) Group
Apr 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jian-Liu WangKeng-Ling Wallin
Feb 24, 2005·Clinical Obstetrics and Gynecology·Michael A BidusG Scott Rose
May 5, 2005·Journal of Lower Genital Tract Disease·L Stewart MassadYvonne C Collins
Apr 14, 2006·Acta Obstetricia Et Gynecologica Scandinavica·André Luis Ferreira SantosKari Juhani Syrjänen
Oct 17, 2006·The Journal of Infectious Diseases·Cosette M WheelerUNKNOWN Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesions Triage Study Group
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Oct 20, 2006·Journal of Lower Genital Tract Disease·Christine MolloyThomas Jenkins
Nov 1, 2006·American Journal of Obstetrics and Gynecology·Robert G PretoriusRaoul J Burchette

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Citations

Apr 30, 2013·Journal de gynécologie, obstétrique et biologie de la reproduction·A-L RobertJ Levêque
Sep 11, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Yoo-Young LeeDuk-Soo Bae
Oct 8, 2011·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Luisa Benerini GattaAnna Benetti

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