Management of cognition and function: new results from the clinical trials programme of Aricept(R) (donepezil HCl)

The International Journal of Neuropsychopharmacology
David S. Knopman

Abstract

Ideally, treatment for Alzheimer's disease (AD) should prevent or cure the disease. Unfortunately, these goals appear unobtainable in the foreseeable future. Nevertheless, symptomatic relief is a feasible treatment option for AD patients and is available currently in the form of cholinesterase inhibitors such as tacrine, donepezil, metrifonate and rivastigmine. Donepezil is a second-generation, piperidine-class, selective and reversible acetylcholinesterase inhibitor. Four double-blind, placebo-controlled clinical trials of donepezil, involving over 1900 individuals with mild to moderate AD, have been published recently. In all trials, significant improvements in cognition were observed consistently for both therapeutic doses of donepezil (5 and 10 mg/d), relative to placebo. Similar donepezil-associated benefits were reported for global functioning. In addition, in one 24-wk, multinational clinical trial, patients receiving donepezil (10 mg/d) performed better than placebo-treated patients in their ability to perform complex daily functioning tasks. Donepezil was well tolerated in all trials, with approx. 79% of all donepezil-treated patients completing the studies compared with approx. 84% of placebo-treated patients. The mos...Continue Reading

Citations

Jan 31, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Paola RoccaFilippo Bogetto
Mar 1, 2005·Multiple Sclerosis : Clinical and Laboratory Research·Nancy D ChiaravallotiJoseph H Ricker
Oct 3, 2020·Bioorganic & Medicinal Chemistry·Priyanka Kumari ChoubeySushant Kumar Shrivastava

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