Management of colonic diverticular disease in the third millennium: Highlights from a symposium held during the United European Gastroenterology Week 2017

Therapeutic Advances in Gastroenterology
Carmelo ScarpignatoLisa L Strate

Abstract

Diverticulosis is a common anatomical condition, which appears to be age-dependent. Individuals who develop chronic gastrointestinal symptoms or complications are referred to as having diverticular disease. Although the diagnosis of this condition can be relatively straightforward, randomized controlled trials are scarce and management often follows tradition rather than principles of evidence-based medicine. This report deals with the topics discussed during a symposium held during the United European Gastroenterology Week (Barcelona, October 2017). During the meeting, the role of dysbiosis in the pathogenesis of diverticular disease and its treatment were thoroughly discussed, by examining the efficacy and mechanisms of action of the currently used drugs. Recent studies have shown the presence of dysbiosis in patients with diverticular disease and suggest an imbalance in favor of bacteria with pro-inflammatory and pathogenetic potential. These microbiota changes correlate with mucosal immune activation, mirrored by a marked increase of macrophages in colonic mucosa, both in the diverticular region and at distant sites. The low-grade inflammation, driven by bacteria-induced immune activation, could be involved in the pathophys...Continue Reading

References

May 22, 1971·British Medical Journal·N S Painter, D P Burkitt
May 16, 1998·The Journal of Nutrition·W H AldooriW C Willett
Mar 2, 2002·The Lancet Infectious Diseases·A SullivanC E Nord
Jul 11, 2003·World Journal of Gastroenterology : WJG·Antonio ColecchiaDavide Festi
Aug 19, 2003·European Journal of Gastroenterology & Hepatology·John SimpsonRobin C Spiller
Feb 14, 2004·Advanced Drug Delivery Reviews·Daniel A SniderWalter Owens
Mar 15, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Gabrio BassottiVincenzo Villanacci
Apr 28, 2005·Chemotherapy·Carmelo Scarpignato, Iva Pelosini
May 11, 2005·World Journal of Gastroenterology : WJG·Antonio TursiWalter Elisei
Feb 25, 2006·Digestion·Giuseppe FrieriCarmelo Scarpignato
May 9, 2006·Gastroenterology·George F LongstrethRobin C Spiller
Jan 20, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Laura W Lamps, Whitfield L Knapple
Mar 22, 2007·Alimentary Pharmacology & Therapeutics·R D'IncàG C Sturniolo
Apr 14, 2007·Diseases of the Colon and Rectum·Tarek A SalemPatrick J O'Dwyer
Sep 2, 2008·Scandinavian Journal of Gastroenterology·Rossella CianciGuido Costamagna
Oct 29, 2009·The American Journal of Gastroenterology·Hye-Kyung JungNicholas J Talley
Nov 26, 2009·Expert Review of Gastroenterology & Hepatology·Giovanni Latella, Carmelo Scarpignato
Aug 14, 2010·Microbiology·Cecilia JernbergJanet K Jansson
Sep 10, 2011·Diseases of the Colon and Rectum·Giovanni MaconiBruno Annibale
Nov 9, 2011·Gastroenterology·Anne F PeeryRobert S Sandler
Mar 20, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Rebecca M Lovell, Alexander C Ford
May 11, 2012·International Journal of Colorectal Disease·Bruno AnnibaleRosario Cuomo
May 12, 2012·International Journal of Colorectal Disease·Cagdas UnlüMarja A Boermeester
Jul 11, 2012·The American Journal of Gastroenterology·Lisa L StrateBrennan M R Spiegel
Oct 25, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Angel LanasFermín Mearin
Jun 19, 2013·Expert Opinion on Pharmacotherapy·Valeria CriscuoliMario Cottone
Jul 17, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Kamyar ShahediBrennan Spiegel
Jul 31, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Anne F PeeryJohn A Baron
Aug 21, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Lillias H MaguireAndrew T Chan
Dec 18, 2013·International Journal of Colorectal Disease·Erman AytacGokhan Ozuner
Jan 5, 2014·Gut·Francesca L CroweUNKNOWN Million Women Study Collaborators
Jan 7, 2014·Alimentary Pharmacology & Therapeutics·D J Humes, R C Spiller
May 8, 2014·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S VennixUNKNOWN Research Committee of the European Society of Coloproctocology
May 20, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Corrado BlandizziCarmelo Scarpignato

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Citations

Dec 30, 2018·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Francesco Di MarioAntonio Tursi
Jul 9, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J K SchultzE Angenete
Mar 29, 2020·Nature Reviews. Disease Primers·Antonio TursiSilvio Danese
Jul 27, 2018·Therapeutic Advances in Gastroenterology·Angel LanasAitor Lanas-Gimeno
Jul 19, 2019·United European Gastroenterology Journal·Cesare CremonGiovanni Barbara
Jul 29, 2019·Cellular and Molecular Gastroenterology and Hepatology·Michael CamilleriAnne F Peery

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