Management of colorectal cancer in patients with inflammatory bowel disease

Techniques in Coloproctology
D O KavanaghD C Winter

Abstract

This study evaluated the clinicopathological features and survival rates of patients with inflammatory bowel disease who developed colorectal cancer (CRC). A retrospective review was performed on a prospectively maintained institutional database (1981-2011) to identify patients with inflammatory bowel disease who developed CRC. Clinicopathological parameters, management and outcomes were analysed. A total of 2,843 patients with inflammatory bowel disease were identified. One thousand six hundred and forty-two had ulcerative colitis (UC) and 1,201 had Crohn's disease (CD). Following exclusion criteria, there were 29 patients with biopsy-proven colorectal carcinoma, 22 of whom had UC and 7 had CD. Twenty-six patients had a preoperative diagnosis of malignancy/dysplasia; 16 of these were diagnosed at surveillance endoscopy. Nodal/distant metastasis was identified at presentation in 47 and 71 % of the UC and CD group, respectively. Operative morbidity for UC and CD was 33 and 17 %, respectively. Despite the less favourable operative outcomes following surgery management of UC-related CRC, overall 5-year survival was significantly better in the UC group compared to the CD group (41 vs. 29 %; p = 0.04) reflecting the difference in st...Continue Reading

References

Nov 22, 1973·The New England Journal of Medicine·D D WeedonW F Taylor
Jul 1, 1971·The New England Journal of Medicine·G J DevroedeG B Stickler
Apr 1, 1982·Annals of Surgery·I C LaveryF L Weakley
Jan 1, 1959·Diseases of the Colon and Rectum·G A HALLENBECK
Dec 31, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Karen V WintherVibeke Binder
Mar 11, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Thierry DelaunoitEdward V Loftus
Jun 15, 2006·The American Journal of Gastroenterology·Ane B JensenHenrik T Sørensen
Aug 22, 2006·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J LindbergJ Rutegård
Sep 6, 2006·Gastroenterology Clinics of North America·Steven H Itzkowitz
Jan 18, 2008·World Journal of Gastroenterology : WJG·Jianlin Xie, Steven H Itzkowitz
Feb 27, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M OuaïssiY Panis
Dec 15, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Mike Georg LaukoetterMatthias Bruewer
Mar 1, 2008·Journal of Crohn's & Colitis·Livia BianconeUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Jun 22, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·F AverboukhH Tulchinsky

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Citations

Aug 15, 2013·Cancer Letters·Gerhard Rogler
Jul 28, 2016·The Journal of Surgical Research·Coen L KlosSekhar Dharmarajan
Dec 4, 2014·World Journal of Gastroenterology : WJG·Masakazu Yashiro
Mar 5, 2020·International Journal of Occupational Safety and Ergonomics : JOSE·Marius D IftimeValentina D Ciobanu
Feb 18, 2017·World Journal of Gastroenterology : WJG·Ivan KristoAnton Stift
Jul 7, 2017·Cancer Metastasis Reviews·Michael LamDavid G Menter
May 22, 2018·Gastroenterology Report·Yu ZhenHu Zhang

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