Management of Common Side Effects of Apremilast

Journal of Cutaneous Medicine and Surgery
Annie Langley, Jennifer Beecker

Abstract

Apremilast is a relatively new therapy for the treatment of moderate to severe plaque psoriasis in adults. While this medication is considered safe with a very low risk of serious side effects, a few common (≥5% of patients) mild to moderate side effects have been reported, including diarrhea, nausea, headache, and nasopharyngitis. Not addressing these symptoms may lead to medication nonadherence and unnecessary discontinuation of therapy. These side effects are often easily managed with interventions available to the practicing dermatologist, and in only rare instances will these side effects require dose adjustment or discontinuation of therapy. The purpose of this article is to review common side effects of apremilast at its approved dose of 30 mg orally twice daily (BID) and to provide clear, simple recommendations for their management in dermatological practice.

References

May 1, 1991·Journal of the American Academy of Dermatology·J D Stratigos
Jan 27, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·O ChassanyJ F Bergmann
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R L GuerrantUNKNOWN Infectious Diseases Society of America
Nov 10, 2007·Current Gastroenterology Reports·Bincy Abraham, Joseph H Sellin
Mar 17, 2009·The Journal of Rheumatology·Dafna D GladmanUNKNOWN Group for Reasearch and Assessment of Psoriasis and Psoriatic Arthritis
Oct 11, 2013·American Journal of Respiratory Cell and Molecular Biology·James A LambertSteven M Rowe
May 7, 2014·Drugs·Raewyn M Poole, Anita D Ballantyne
Jan 31, 2017·Expert Opinion on Drug Safety·A DattolaL Bianchi

❮ Previous
Next ❯

Citations

Jan 25, 2019·Drug Discoveries & Therapeutics·Bipadabhanjan MallickSarat C Panigrahi
Sep 5, 2020·Expert Opinion on Drug Safety·Giuseppe LopalcoFlorenzo Iannone
Sep 11, 2020·Actas dermo-sifiliográficas·E Daudén TelloL Salgado-Boquete
May 11, 2021·Clinical and Experimental Dermatology·A PacificoG Damiani
Aug 26, 2021·Psoriasis : Targets and Therapy·Murlidhar RajagopalanPravin Banodkar
Dec 23, 2019·Actas dermo-sifiliográficas·J M CarrascosaP Herranz
Feb 12, 2021·Case Reports in Dermatology·Eleftherios Ntouniadakis, Fredrik Landström

❮ Previous
Next ❯

Methods Mentioned

BETA
gastric bypass

Clinical Trials Mentioned

NCT01194219
NCT01232283
NCT01172938
NCT01212757
NCT01212770

Software Mentioned

ESTEEM
PALACE
LIBERATE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research
M BarbieriB Oskar
Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research
J M CarrascosaT Tencer
Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research
F MughalF Zhang
Journal of Medicinal Chemistry
S M ThacherR A Chandraratna
© 2022 Meta ULC. All rights reserved