Management of Cutaneous and Extracutaneous Side Effects of Smoothened Inhibitor Therapy for Advanced Basal Cell Carcinoma

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Shalini V Mohan, Anne Lynn S Chang

Abstract

Smoothened inhibitors represent the first class of targeted drugs approved for use in advanced and metastatic basal cell carcinoma. For many patients with limited treatment options, this drug class has led to significant clinical improvements, but is not without side effects. In this review, we outline the basic mechanism of smoothened inhibitors and the most commonly observed cutaneous and extracutaneous side effects. We also highlight possible mechanisms for these adverse events and current management strategies.

References

Jan 12, 1999·Developmental Biology·C ChiangA A Dlugosz
Jul 27, 2002·Journal of the American College of Cardiology·Richard C PasternakUNKNOWN National Heart, Lung and Blood Institute
Jan 2, 2003·Current Topics in Developmental Biology·Andrew P McMahonClifford J Tabin
Mar 22, 2003·Developmental Biology·Anthony E Oro, Kay Higgins
Mar 22, 2003·Developmental Biology·Joshua M H HallThomas E Finger
Jan 23, 2004·Nature Reviews. Cancer·Marina Pasca di Magliano, Matthias Hebrok
Jul 9, 2004·BMC Developmental Biology·Xiaopeng LiSimon M Hughes
Dec 8, 2004·Developmental Biology·Hong-Xiang LiuCharlotte M Mistretta
Apr 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yukiko MaedaBeate Lanske
Jun 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cheong J LeeDiane M Simeone
Jun 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Xing Fan, Charles G Eberhart
Jul 30, 2008·Journal of Cellular and Molecular Medicine·Giuseppe StrafaceRoberto Pola
Sep 17, 2008·Clinical Colorectal Cancer·Teresa MacarullaJosep Tabernero
May 16, 2009·Trends in Pharmacological Sciences·Suzie J Scales, Frederic J de Sauvage
Nov 26, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Loren K MellRalph R Weichselbaum
May 1, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Begoña OchoaAnna Mae Diehl
Feb 9, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Patricia M LoRussoDaniel D Von Hoff
Mar 15, 2011·Cellular Signalling·Chengxin LiJingwu Xie
Oct 19, 2011·Proceedings of the National Academy of Sciences of the United States of America·Nicholas J WangRaymond J Cho
Dec 7, 2011·The Journal of Physiology·Juanita L Merchant
Jun 8, 2012·The New England Journal of Medicine·Aleksandar SekulicAxel Hauschild
Aug 17, 2012·Future Oncology·Luc Dirix, Annemie Rutten
Apr 12, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Antonio JimenoCharles M Rudin
Jun 19, 2013·Journal of the American Academy of Dermatology·Amy IarrobinoVernon K Sondak
Jul 6, 2013·American Journal of Epidemiology·Shaowei WuAbrar A Qureshi
Aug 7, 2013·Developmental Biology·Hong Xiang LiuCharalotte M Mistretta
Oct 22, 2013·OncoTargets and Therapy·Jingwu XieDongsheng Gu
Nov 6, 2013·Journal of the American Academy of Dermatology·Anne Lynn S ChangGlen J Weiss
Nov 6, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Oriana YuLaurent Azoulay
Feb 14, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jordi RodonAlain C Mita
Feb 18, 2014·Journal of the American Academy of Dermatology·Thomas LamCarrie L Davis
Jun 16, 2014·Journal of the American Academy of Dermatology·Mina Sarah AllyJean Yuh Tang
Jul 2, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·C SaintesB Dréno
Jul 20, 2014·Journal of the American Academy of Dermatology·Daniel J Ventarola, David I Silverstein
Nov 14, 2014·Journal of Neurophysiology·Archana KumariCharlotte M Mistretta

❮ Previous
Next ❯

Citations

Jan 23, 2016·Annales de dermatologie et de vénéréologie·N Meyer
Feb 18, 2016·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Mareike AlterRalf Gutzmer
Mar 25, 2016·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Yaakov CassAlexander Tabachnik
Jun 20, 2017·The British Journal of Dermatology·C DessiniotiA J Stratigos
Jan 10, 2018·Medicinal Research Reviews·Minhang XinBinghe Wang
Aug 9, 2018·American Journal of Clinical Dermatology·Poonkiat Suchonwanit, Amy J McMichael
May 22, 2020·JCI Insight·Hélène ChoquetEric Jorgenson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Hand : Official Journal of the American Association for Hand Surgery
Gefei Alex ZhuAnne Lynn S Chang
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Manish R SharmaEzra E W Cohen
Molecular Cancer Therapeutics
Nicole Basset-SeguinFrederic J de Sauvage
© 2021 Meta ULC. All rights reserved