Management of Difficult Cases of Autoimmune Hepatitis

Current Gastroenterology Reports
Craig LammertSamer Gawrieh

Abstract

Autoimmune hepatitis (AIH) is a complex autoimmune disease characterized by immune-mediated destruction of hepatic parenchyma which can result in cirrhosis, liver failure, and death. Current American Association for the Study of Liver Diseases (AASLD) and European Association for the Study of Liver (EASL) guidelines recommend corticosteroids alone or in combination with azathioprine as first-line treatment strategies. However, a significant proportion of patients may not be able to tolerate or achieve complete biochemical response with these options. In this article, we discuss approaches to these patients and other challenging AIH patient groups such as the asymptomatic, pregnant, elderly, and liver transplant recipients.

References

Apr 1, 1971·The Quarterly Journal of Medicine·G C CookS Sherlock
Mar 1, 1996·Gastroenterology·S K RobertsA J Czaja
Feb 6, 1999·The American Journal of Gastroenterology·N F FernandesT L Fong
Mar 20, 1999·Science·C C WhitacreP A O'Looney
Aug 1, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G AyataU Khettry
Dec 15, 2000·Gut·M A HeneghanI G McFarlane
Apr 17, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A González-KochR H Wiesner
Jun 21, 2001·Zeitschrift für Gastroenterologie·S KanzlerA W Lohse
May 31, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Albert J Czaja
Jun 25, 2002·Journal of Clinical Gastroenterology·Jacob KoganYaron Ilan
Mar 20, 2004·Journal of Hepatology·Albert J Czaja, Herschel A Carpenter
Apr 9, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Nanda KerkarSukru Emre
Jun 15, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordan J FeldE Jenny Heathcote
Feb 9, 2006·The American Journal of Gastroenterology·Christoph SchrammAnsgar W Lohse
Apr 25, 2006·Alimentary Pharmacology & Therapeutics·Y MiyakeY Shiratori
Jun 27, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Vimala ChristopherMichael A Heneghan
Mar 21, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Philippe IchaiDidier Samuel
Jul 7, 2007·Scandinavian Journal of Gastroenterology·Mårten WernerAke Danielsson
Aug 3, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Aldo J Montano-LozaAlbert J Czaja
Aug 21, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sumita VermaPaul J Thuluvath
Nov 9, 2007·Alimentary Pharmacology & Therapeutics·C W LeesI D R Arnott
Jul 23, 2008·Journal of Clinical Gastroenterology·Stefan LüthAnsgar W Lohse
Oct 16, 2008·The American Journal of Gastroenterology·Elke M HennesAnsgar W Lohse
Nov 21, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Albert J Czaja
Oct 1, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Aldo J Montano-LozaPuneeta Tandon
Oct 31, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jean-Charles Duclos-Vallee, Mylène Sebagh
Jan 20, 2010·Scandinavian Journal of Gastroenterology·Mårten WernerAke Danielsson
Jun 1, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael P MannsUNKNOWN American Association for the Study of Liver Diseases
Jul 6, 2010·Gastroenterology·Michael P MannsUNKNOWN European AIH-BUC-Study Group
Oct 12, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Luigi MuratoriMarco Lenzi
Nov 3, 2010·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Kaveh SharzehiKimberly A Brown
Jul 6, 2011·Alimentary Pharmacology & Therapeutics·M M TannousR Sterling
Jan 21, 2012·Journal of Autoimmunity·Rachel H WestbrookMichael A Heneghan
Feb 10, 2012·American Journal of Medical Genetics. Part a·Maria HoeltzenbeinChristof Schaefer
Apr 11, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Harpreet K DhaliwalLynne Lennard
Sep 15, 2012·Current Pharmaceutical Design·L PorcelliA Azzariti
Oct 16, 2012·Expert Review of Gastroenterology & Hepatology·Albert J Czaja
Dec 15, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Safa Al-ShammaSimon Mclaughlin
Jan 30, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jing Hieng NguCatherine A M Stedman
Apr 27, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M KimS Gabardi

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Citations

Jun 19, 2019·Clinical and Translational Gastroenterology·Craig LammertElizabeth J Phillips
Sep 29, 2020·Journal of Translational Internal Medicine·Abbas Ali Tasneem, Nasir Hassan Luck

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