Management of drug-resistant tuberculosis in special sub-populations including those with HIV co-infection, pregnancy, diabetes, organ-specific dysfunction, and in the critically ill

Journal of Thoracic Disease
Aliasgar EsmailKeertan Dheda

Abstract

Tuberculosis remains a major problem globally, and is the leading cause of death from an infectious agent. Drug-resistant tuberculosis threatens to marginalise the substantial gains that have recently been made in the fight against tuberculosis. Drug-resistant TB has significant associated morbidity and a high mortality, with only half of all multidrug-resistant TB patients achieving a successful treatment outcome. Patients with drug-resistant TB in resource-poor settings are now gaining access to newer and repurposed anti-tuberculosis drugs such as bedaquiline, delamanid and linezolid. However, with ever increasing rates of co-morbidity, there is little guidance on how to manage complex patients with drug-resistant TB. We address that knowledge gap, and outline principles underpinning the management of drug-resistant TB in special situations including HIV co-infection, pregnancy, renal disease, liver disease, diabetes, and in the critically ill.

Citations

Nov 16, 2019·American Journal of Respiratory and Critical Care Medicine·Payam NahidBarbara Seaworth
Sep 20, 2020·BMC Infectious Diseases·Brittney J van de WaterMercedes C Becerra
Sep 13, 2020·Current HIV/AIDS Reports·Elisa H Ignatius, Susan Swindells
Sep 2, 2020·Antimicrobial Agents and Chemotherapy·Martina L ReichmuthPeter M Keller
Oct 18, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·K A AleneA A Adane
Feb 9, 2021·Journal of Clinical Tuberculosis and Other Mycobacterial Diseases·Joseph Baruch BalukuWilliam Worodria
Feb 22, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Joseph Baruch Baluku, Felix Bongomin
Sep 19, 2019·Lancet·Christoph LangeC Robert Horsburgh
Dec 16, 2021·Journal of the International AIDS Society·Anne Drapkin LyerlyLeslie Wolf

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