MANAGEMENT OF ENDOCRINE DISEASE: Adrenocortical carcinoma: differentiating the good from the poor prognosis tumors

European Journal of Endocrinology
Anne Jouinot, Jérôme Bertherat

Abstract

Adrenocortical carcinoma (ACC) is a rare malignancy with a poor prognosis, the five-years overall survival being below 40%. However, there is great variability of outcomes and we have now a better view of the heterogeneity of tumor aggressiveness. The extent of the disease at the time of diagnosis, best assayed by the European Network for the Study of Adrenal Tumors (ENSAT) Staging Score, is a major determinant of survival. The tumor grade, including the mitotic count and the Ki67 proliferation index, also appears as a strong prognostic factor. The assessment of tumor grade, even by expert pathologists, still suffers from inter-observer reproducibility. The emergence of genomics in the last decade has revolutionized the knowledge of molecular biology and genetics of cancers. In ACC, genomic approaches - including pan-genomic studies of gene expression (transcriptome), recurrent mutations (exome or whole-genome sequencing), chromosome alterations, DNA methylation (methylome), miRNA expression (miRnome) - converge in a new classification of ACC, characterized by distinct molecular profiles and very different outcomes. Targeted measurements of a few discriminant molecular alterations have been developed in the perspective of clini...Continue Reading

References

Dec 1, 1978·The Journal of Urology·M SullivanC V Hodges
Apr 26, 1990·The New England Journal of Medicine·J P LutonP Blondeau
Mar 1, 1989·The American Journal of Surgical Pathology·L M WeissA L Vickery
Mar 1, 1984·The American Journal of Surgical Pathology·L M Weiss
Jun 1, 1993·Journal of Pediatric Surgery·C C SabbagaD Blucher
Aug 18, 2001·Journal of Endocrinological Investigation·I IliasA Souvatzoglou
Feb 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alexander StojadinovicMurray F Brennan
Jul 11, 2002·The Journal of Clinical Endocrinology and Metabolism·Stan SidhuBruce G Robinson
Apr 1, 1997·Endocrine Pathology·Anne M. McNicolHarm R. Haak
Oct 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Diva D De LeónThomas Moshang
Jul 31, 2003·International Journal of Urology : Official Journal of the Japanese Urological Association·Yasuhisa FujiiKazunori Kihara
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E MichalkiewiczR C Ribeiro
Jun 10, 2005·Nature·Jun LuTodd R Golub
May 9, 2006·World Journal of Surgery·Electron KebebewAlex McMillan
Aug 10, 2006·The Journal of Clinical Endocrinology and Metabolism·Martin FassnachtBruno Allolio
Sep 19, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Marco VolanteMauro Papotti
Oct 26, 2006·The Journal of Clinical Endocrinology and Metabolism·Guillaume AssiéEric Baudin
Dec 26, 2006·Surgery·B Lauren PatonB Todd Heniford
Feb 10, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rossella LibèJérôme Bertherat
Feb 19, 2008·Molecular Cancer Therapeutics·Elizabeth A StephanMichael J Demeure
Jan 14, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aurélien de ReynièsJérôme Bertherat
Jan 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thomas J GiordanoGary Hammer
May 5, 2009·European Journal of Endocrinology·Cecilia LaurellMartin Bäckdahl
Jun 6, 2009·BJU International·Laurent ZiniPierre I Karakiewicz
Dec 10, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Patsy Siok Hwa SoonStan B Sidhu
Jan 2, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Giovanni LughezzaniPierre I Karakiewicz
Jul 28, 2010·The Journal of Clinical Endocrinology and Metabolism·Silviu SbieraMartin Fassnacht
Jul 30, 2010·The Journal of Clinical Endocrinology and Metabolism·Martin FassnachtUNKNOWN German ACC Registry Group
Aug 10, 2010·Langenbeck's Archives of Surgery·Barbra S MillerGerard M Doherty
Nov 23, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sébastien GaujouxFrédérique Tissier
Aug 24, 2011·Endocrine-related Cancer·Deniz M ÖzataWeng-Onn Lui
Oct 1, 2011·Journal of the National Cancer Institute·Mitch DowsettUNKNOWN International Ki-67 in Breast Cancer Working Group

❮ Previous
Next ❯

Citations

Sep 18, 2018·Minerva endocrinologica·Rossella Libé
Nov 6, 2018·Pediatric Surgery International·Zuopeng WangShan Zheng
Mar 15, 2019·Journal of Molecular Endocrinology·Norman G NicolsonTobias Carling
Dec 12, 2018·Endocrine Connections·Anne JouinotBenoit Blanchet
Apr 11, 2019·European Journal of Endocrinology·Alfredo BerrutiMassimo Terzolo
Apr 14, 2019·Endocrine·Iiro KostiainenCamilla Schalin-Jäntti
Jun 4, 2019·Frontiers in Endocrinology·Weiwei Liang, Fangfang Sun
Oct 19, 2019·Arkhiv patologii·L S SelivanovaG A Melnichenko
Feb 25, 2019·Current Oncology Reports·Sina Jasim, Mouhammed Amir Habra
Aug 13, 2020·Cancers·Marthe ChehadeStan Sidhu
Jul 12, 2019·JAMA Oncology·Guillaume AssiéJérôme Bertherat
Jan 14, 2021·ANZ Journal of Surgery·Burak ArdicliSaniye Ekinci
Mar 3, 2021·Journal of Cellular and Molecular Medicine·Adele ChimentoVincenzo Pezzi
Mar 30, 2021·Frontiers in Endocrinology·Weiwei Liang, Fangfang Sun
Mar 21, 2021·Current Opinion in Endocrinology, Diabetes, and Obesity·Padraig Donlon, Michael Conall Dennedy
Nov 6, 2021·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Christos ParianosEva Kassi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Adrenocortical Carcinoma

Adrenocortical carcinoma (ACC) is a rare malignancy of the adrenal cortex, associated with a generally dismal prognosis owing to its aggressive behavior. Here are the latest discoveries pertaining to this disease.

Cancer -Omics

A variety of different high-throughput technologies can be used to identify the complete catalog of changes that characterize the molecular profile of cohorts of tumor samples. Discover the latest insights gained from cancer 'omics' in this feed.