Management of Enteral Nutrition in the Pediatric Intensive Care Unit: Prokinetic Effects of Amoxicillin/Clavulanate in Real Life Conditions

Pediatric Gastroenterology, Hepatology & Nutrition
Fabrizio ChiusoloAntonella Diamanti

Abstract

Malnutrition is a common feature in critically ill children. Enteral nutrition (EN) is the main strategy to nutritionally support critical ill children, but its use can be hindered by the development of intolerance. The study aimed to assess the effectiveness and safety of amoxicillin/clavulanate (A/C) to treat EN intolerance. We retrospectively evaluated patients admitted to the pediatric intensive care unit from October 2018 to October 2019. We conducted a case-control study: in the first 6 months (October 2018-April 2019) we implemented the nutritional protocol of our Institution with no drug, whereas in the second half (May 2019-October 2019) we employed A/C for 1 week at a dose of 10 mg/kg twice daily. Twelve cases were compared with 12 controls. At the final evaluation, enteral intake was significantly higher than that at baseline in the cases (from 2.1±3.7 to 66.1±27.4% of requirement, p=0.0001 by Wilcoxon matched-pairs signed rank test) but not in the controls (from 0.2±0.8 to 6.0±14.1% of the requirement, p=NS). Final gastric residual volume at the end of the observation was significantly lower in the cases than in the controls (p=0.0398). The drug was well tolerated as shown by the similar safety outcomes in both case...Continue Reading

References

Feb 1, 1986·Digestive Diseases and Sciences·T TomomasaZ Itoh
Sep 12, 2009·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·R MeyerD Labadarios
Nov 26, 2009·Pediatric Clinics of North America·Nilesh M Mehta, Christopher P Duggan
May 11, 2010·Journal of Pediatric Gastroenterology and Nutrition·Christian BraeggerJohannes van Goudoever
May 16, 2012·Journal of Pediatric Gastroenterology and Nutrition·Roberto GomezCarlo Di Lorenzo
Mar 27, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Nilesh M MehtaUNKNOWN American Society for Parenteral and Enteral Nutrition Board of Directors
Nov 26, 2014·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Patricia BeckerUNKNOWN American Society for Parenteral and Enteral Nutrition
Mar 26, 2015·Journal of Pediatric Gastroenterology and Nutrition·Jessica E EricsonUNKNOWN Best Pharmaceuticals for Children Act–Pediatric Trials Network Administrative Core Committee
Aug 4, 2015·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Michael F CanarieUNKNOWN Northeast Pediatric Critical Care Research Consortium
Mar 16, 2016·The New England Journal of Medicine·Tom FivezGreet Van den Berghe
Jul 12, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Nilesh M MehtaCarol Braunschweig
Dec 16, 2017·Paediatric Drugs·Mhd Louai ManiniCarlo Di Lorenzo
Dec 19, 2017·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Jason G LakeIsaac See
Mar 24, 2018·Journal of Pediatric Gastroenterology and Nutrition·Nikhil ThaparCarlo Di Lorenzo

❮ Previous
Next ❯

Software Mentioned

GraphPad
Graph Pad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved