PMID: 11905505Mar 22, 2002Paper

Management of erythema nodosum leprosum by thalidomide: thalidomide analogues inhibit M. leprae-induced TNFalpha production in vitro

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
E P SampaioE N Sarno

Abstract

Thalidomide is being successfully used for the treatment of erythema nodosum leprosum (ENL), among other disorders with inflammatory and immunological bases. Although the active molecules responsible for the diverse therapeutic activities of the drug and the sequence of reactions triggered inside the cells remain unclear, it was demonstrated that thalidomide (THAL) inhibits TNFalpha mRNA expression and protein production by stimulated monocytes and activated T lymphocytes. Patients treated with THAL experienced a reduction in serum TNFalpha levels and it diminished cytokine gene expression at the lesion site, with a concomitant abrogation of clinical symptoms. It has been reported that thalidomide as well as some its analogues decrease M. leprae-induced TNFalpha and IL-12 mRNA in vitro. THAL also reduced monocyte apoptosis in the cultures. The present data further support thalidomide's effects on TNFa synthesis and the growing need to search for new specific TNFalpha inhibitors (non-teratogenic compounds) that might be potentially used in clinical disorders such as leprosy.

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Citations

Apr 17, 2003·Postgraduate Medical Journal·J N Gordon, P M Goggin
Oct 19, 2006·Mediators of Inflammation·Peng LvHesheng Luo
May 17, 2003·Clinical Therapeutics·S James Matthews, Christopher McCoy
Oct 21, 2011·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·T LunaA R Jesus
Jan 26, 2006·Expert Opinion on Pharmacotherapy·Ramón García-Sanz
Jun 20, 2012·Innate Immunity·Alexander PuzikChristoph Härtel
Jul 12, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J A LimaA C Pinto
Sep 17, 2004·Muscle & Nerve·Winnie W Ooi, Jayashri Srinivasan
Sep 1, 2006·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Shelley Chireyath PaulHe-Sheng Luo

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