Management of gastrointestinal complications in hereditary transthyretin amyloidosis: a single-center experience over 40 years

Expert Review of Gastroenterology & Hepatology
Jonas WixnerIntissar Anan

Abstract

Hereditary transthyretin amyloidosis (ATTRm amyloidosis) is a rare disease caused by the deposition and accumulation of insoluble non-native transthyretin fibrils in the body. The disease inevitably results in widespread organ disruption, and poor life expectancy. The GI tract is one organ system vulnerable to disruption and, although the clinical presentation of the disease varies, GI involvement affects most patients with ATTRm amyloidosis. Areas covered: This article presents our experience with diagnosing and treating the GI symptoms of ATTRm amyloidosis patients at our center over the last 40 years, in the Swedish clustering area of the disease. Our aim is to help other physicians to better manage GI complications in patients with this rare but widespread condition. Expert commentary: GI symptoms are debilitating complications for ATTRm amyloidosis patients to experience, yet with the appropriate questioning and diagnosis methods, symptomatic treatments of these symptoms can be implemented to provide relief. Further, patients with fewer GI complications and a good nutritional status are also better candidates for liver transplantation which, in selected cases, is the best disease-modifying treatment of ATTRm amyloidosis to...Continue Reading

References

Dec 1, 1976·Gut·E H Thaysen, L Pedersen
Sep 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·M CarvalhoM L Luis
Jan 1, 1991·Scandinavian Journal of Gastroenterology. Supplement·H P Festen
May 1, 1989·Journal of Internal Medicine·B O OlofssonF Lithner
Jun 28, 1985·Biochemical and Biophysical Research Communications·M R WallaceM D Benson
Dec 1, 1983·Journal of Clinical Pathology·L B TehD P Jewell
Nov 1, 1994·Digestive Diseases and Sciences·B RamirezC A Sninsky
Jan 1, 1993·Clinical Physiology·P BjerleL Steen
Nov 6, 1996·Journal of the Autonomic Nervous System·Y AndoM Ando
Feb 1, 1997·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·G Schreiber, S J Richardson
Jun 3, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E Husebye
Jun 11, 1999·Journal of Internal Medicine·I AnanO Suhr
Aug 10, 1999·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·K TashimaM Uchino
Mar 22, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M B Pepys
Apr 11, 2001·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·E JonsénE Athlin
Sep 11, 2003·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Ole B SuhrAnders Rydh
Jul 9, 2004·Current Treatment Options in Gastroenterology·Greg Lyford, Amy Foxx-Orenstein
May 12, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·I M ConceiçãoM A de Carvalho
Jun 21, 2005·Alimentary Pharmacology & Therapeutics·E C LauritanoA Gasbarrini
Jan 9, 2007·European Journal of Gastroenterology & Hepatology·Guillaume GourcerolPhilippe Ducrotte
Apr 25, 2007·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Idalina BeirãoGraça Porto
Oct 18, 2008·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Urban HellmanViolaine Planté-Bordeneuve
Jul 9, 2010·The Cochrane Database of Systematic Reviews·Heather Lee-RobichaudRichard L Nelson
Aug 1, 2010·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Uazman AlamRayaz Ahmed Malik
Mar 6, 2012·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Cecília MonteiroRicardo Taipa
Aug 18, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J WixnerO B Suhr
Feb 22, 2013·Orphanet Journal of Rare Diseases·Yukio AndoFabrizio Salvi
May 7, 2013·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Jonas WixnerIntissar Anan
May 15, 2013·Expert Opinion on Pharmacotherapy·Julie E StevensMichael Horowitz

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Citations

Sep 20, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Marjanne den Braber-YmkerIris D Nagtegaal
Oct 9, 2018·Acta Neurologica Scandinavica·Josef FinstererWolfgang Grisold
Feb 20, 2020·Journal of Clinical Neuromuscular Disease·Coreen Schwartzlow, Mohamed Kazamel
Sep 12, 2019·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Thierry Gendre, Violaine Planté-Bordeneuve
Aug 28, 2019·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Laura Obici, Ole B Suhr
Dec 4, 2019·Nutrición hospitalaria·María Teresa Fernández LópezJosé Antonio Mato Mato
Aug 11, 2019·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Isabel Conceição
Oct 10, 2020·Orphanet Journal of Rare Diseases·Hedvig Paulsson RokkeJonas Wixner
Jan 5, 2021·European Journal of Gastroenterology & Hepatology·Radislav NakovJonas Wixner
Apr 3, 2020·Acta Haematologica·M Teresa CibeiraJoan Bladé

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