Management of glucocorticoid-induced osteoporosis.

Nature Reviews. Rheumatology
Juliet E Compston

Abstract

Glucocorticoid-induced osteoporosis is a common condition that results in significant morbidity and mortality. The skeletal effects of glucocorticoids include both direct and indirect actions on bone that result in an early, transient increase in bone resorption accompanied by a decrease in bone formation, which is maintained for the duration of glucocorticoid therapy. Rapid bone loss and increased fracture risk occur soon after the initiation of glucocorticoid therapy and are dose dependent. The increase in fracture risk is partly independent of bone mineral density, probably as a result of changes in bone material properties and an increased risk of falling. Bisphosphonates are the front-line choice for prevention of fracture in glucocorticoid-treated patients, with teriparatide as the second-line option; calcium and vitamin D supplements should be co-prescribed in the majority of individuals. Future guidelines for the management of glucocorticoid-induced osteoporosis should recognize the limitations of FRAX in assessing fracture risk in glucocorticoid-treated patients, and should include recently approved interventions, such as zoledronate and teriparatide.

References

Apr 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D W Dempster
Aug 1, 1995·The Journal of Allergy and Clinical Immunology·J H ToogoodD Drost
May 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D ChappardM Audran
Aug 7, 1997·The New England Journal of Medicine·J D AdachiA A Chines
Aug 17, 1999·The Journal of Clinical Investigation·R L JilkaS C Manolagas
Mar 4, 2000·QJM : Monthly Journal of the Association of Physicians·T P van StaaC Cooper
May 5, 2000·The Cochrane Database of Systematic Reviews·J HomikM Suarez-Almazor
May 10, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N E LaneC D Arnaud
Jun 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T P Van StaaC Cooper
Jun 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D M ReidJ P Devogelaer
Jan 10, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L Dalle CarbonareP J Meunier
Mar 30, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T P van StaaC Cooper
Aug 16, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T P van StaaC Cooper
Oct 16, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T P van StaaC Cooper
Nov 12, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J D RingeF Sorenson
Jan 24, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Florent RichyJean-Yves Reginster
Feb 27, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Tjeerd-Pieter van StaaCyrus Cooper
May 6, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·John A KanisDan Mellstrom
Feb 22, 2005·Biochemical and Biophysical Research Communications·Keizo OhnakaRyoichi Takayanagi
Mar 8, 2005·Journal of Bone and Mineral Metabolism·Hajime NawataUNKNOWN Subcommittee to Study Diagnostic Criteria for Glucocorticoid-Induced Osteoporosis
Jul 30, 2005·Arthritis and Rheumatism·Jeffrey R CurtisKenneth G Saag
Sep 1, 2005·Current Osteoporosis Reports·Ernesto Canalis
Sep 6, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Adrianne C FeldsteinMichael Herson
Oct 12, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Jean-Pierre DevogelaerYves Boutsen
Feb 24, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nancy E LaneLynda F Bonewald
May 4, 2006·Clinical Rheumatology·Margaret GourlayYevgeniy Sheyn

❮ Previous
Next ❯

Citations

Jul 26, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J DevineW Davies
Oct 7, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C RouxP N Sambrook
Mar 22, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S LekamwasamUNKNOWN Joint IOF-ECTS GIO Guidelines Working Group
Nov 16, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D Brask-LindemannB Abrahamsen
Aug 11, 2012·Calcified Tissue International·R RizzoliJ Y Reginster
Nov 8, 2011·Rheumatology International·Kun-Juan ZhangDong-Gang Liu
Oct 15, 2011·Arthritis Research & Therapy·Piet Geusens, Willem F Lems
May 26, 2012·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Mona H IsmailAbdulaziz Alquorain
Jul 13, 2012·Clinical Medicine : Journal of the Royal College of Physicians of London·Mark S Cooper
Sep 21, 2010·Joint, Bone, Spine : Revue Du Rhumatisme·Mickaël Rousière
Mar 5, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Leonardo MellibovskyAdolfo Díez-Perez
Nov 15, 2011·Reumatología clinica·Lluís Pérez EdoUNKNOWN Spanish Society of Rheumatology
Oct 25, 2011·The American Journal of Medicine·Juliet E CompstonUNKNOWN Glow Investigators
Mar 7, 2015·The Tohoku Journal of Experimental Medicine·Minori KurahashiKin-ya Kubo
Jul 2, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Karen E HansenRobert A Adler
Jun 16, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·D J Betteridge
Jul 13, 2011·The Mount Sinai Journal of Medicine, New York·Cathleen Colón-EmericElizabeth Haney
Sep 10, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lijie ShiThomas Remer
May 7, 2015·Journal of Bone and Mineral Metabolism·Hayato KinoshitaYoichi Shimada
Jan 21, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R A OvermanJ B Layton
Dec 25, 2012·Autoimmunity Reviews·Luciana P C SeguroYehuda Shoenfeld
Nov 2, 2013·The Journal of Allergy and Clinical Immunology·Bjoern BuehringWilliam Busse
Jun 3, 2015·Neuro-oncology Practice·Patrick RothMichael Weller
Nov 12, 2014·Nature Reviews. Rheumatology·René Rizzoli, Emmanuel Biver
Aug 26, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L P C SeguroR M R Pereira
Jul 29, 2016·Transplantation·María José Pérez-SáezJulio Pascual

❮ Previous
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