Management of ground-glass opacities in the lung cancer spectrum

The Annals of Thoracic Surgery
Yang ZhangHaiquan Chen

Abstract

Along with the popularity of low-dose computed tomography lung cancer screening, an increasing number of lung ground-glass opacity (GGO) lesions are detected. This review focuses on lung adenocarcinoma manifesting as GGO. We performed a literature search of the PubMed/MEDLINE database to identify articles reporting GGO. The following terms were used: GGO, ground-glass opacity, GGN, ground-glass nodule, part-solid nodule, and subsolid nodule. GGO is a non-specific radiologic finding showing a hazy opacity without blocking underlying pulmonary vessels or bronchial structures. The pathology of GGO can be benign, pre-invasive or invasive adenocarcinoma. Although radiographic features may indicate malignancy, a short period of follow-up is the optimal method to distinguish between benign and malignant GGO lesions. Pathologically, not only lepidic but also non-lepidic growth patterns can present as GGO. Lung adenocarcinoma with GGO component is associated with excellent survival compared to solid lesions. Moreover, there are distinct prognostic factors in patients with lung adenocarcinoma manifesting as GGO or solid lesions. For selected GGO-featured lung adenocarcinoma, sublobar resection with selective or no mediastinal lymph node ...Continue Reading

Citations

Mar 18, 2021·Interactive Cardiovascular and Thoracic Surgery·Yasuo SekineHidehisa Hoshino
Mar 24, 2021·Journal of Cardiothoracic Surgery·Shengcheng LinZhentao Yu
Apr 9, 2021·Journal of Cancer Research and Clinical Oncology·Haoxuan WuHaiquan Chen
Mar 14, 2021·American Journal of Epidemiology·Maria Teresa LandiStephen J Chanock
Jun 5, 2021·Seminars in Thoracic and Cardiovascular Surgery·Jinglei LaiHaiquan Chen
Jul 4, 2021·Seminars in Thoracic and Cardiovascular Surgery·Zelin MaHaiquan Chen
Dec 4, 2021·Journal of Chest Surgery·Seung Hwan SongSungsoo Lee

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