Management of HCV infection and liver transplantation.

International Journal of Medical Sciences
Thomas D Schiano, Paul Martin

Abstract

A major challenge facing liver transplant recipients and their physicians is recurrence of hepatitis C virus infection following otherwise technically successful liver transplantation. Recurrent infection leads to diminished graft and patient survival. Although a number or predictors of severe recurrence have been identified, no definitive strategy has been developed to prevent recurrence. Generally the tempo of hepatitis C recurrence is gauged by serial liver biopsies with the decision to intervene with antiviral therapy based on local philosophy and expertise. Treating hepatitis C in this population has a number of major challenges including diminished patient tolerance for side-effects as well as managing the patient's immunesuppression. However sustained viral responses are possible with the potential to reduce the impact of recurrent hepatitis on the graft. However recurrent hepatitis C virus infection will remain the most frequent form of recurrent disease in liver transplant programs for the foreseeable future.

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Citations

Mar 16, 2013·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S HorsterH Diepolder
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Nov 8, 2017·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Alexandra FreyKerstin Herzer

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Methods Mentioned

BETA
biopsies
biopsy

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