Management of HCV patients in cases of direct-acting antiviral failure

Expert Review of Gastroenterology & Hepatology
C Nelson HayesKazuaki Chayama

Abstract

Introduction: Over 70 million people are infected with hepatitis C virus (HCV), increasing the risk of cirrhosis and hepatocellular carcinoma. Areas covered: Since the approval of the first interferon-free direct-acting antiviral (DAA) therapy in 2011, a number of DAAs have been approved, and HCV is now considered curable. Until recently, however, there were no clear guidelines on how to re-treat patients who fail DAA therapy. Current protease inhibitors (PIs) are generally unaffected by earlier resistance-associated variants (RAVs), but many NS5A inhibitors continue to have overlapping resistance profiles, and NS5A RAVs can persist even in the absence of DAAs. Expert opinion: Fortunately, RAVs affecting NS5B polymerase inhibitors are rare, making sofosbuvir a safe choice as the backbone of re-treatment therapies. Recent re-treatment guidelines that take into account genotype, fibrosis, treatment history, and RAV suggest that >90% of patients with prior treatment failures can be successfully re-treated with sofosbuvir/velpatasvir, sofosbuvir/velpatasvir/voxilaprevir or glecaprevir/pibrentasvir.

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May 6, 2020·PloS One·Felix PiechaJulian Schulze Zur Wiesch
Apr 29, 2020·Cold Spring Harbor Perspectives in Medicine·Johannes SchwerkMichael Gale
Jul 31, 2021·World Journal of Gastroenterology : WJG·María B PisanoPamela Valva

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