Management of hepatitis C patients with decompensated liver disease

Expert Review of Gastroenterology & Hepatology
Ching-Sheng Hsu, Jia-Horng Kao

Abstract

Little is known about the tolerance and effectiveness of novel oral direct acting antivirals (DAA) in hepatitis C patients with decompensated cirrhosis. To examine the studies relevant to the treatment of hepatitis C virus(HCV)-related decompensated liver disease, we performed computer-based searches for English articles between 1947 and August 2015. Fourteen articles including HCV patients with decompensated cirrhosis were reviewed. The combinations of ledipasvir(LDV)/sofosbuvir(SOF)/ribavirin(RBV) for 12 weeks, or daclatasvir/SOF/RBV for 12 weeks are safe and effective for HCV genotype 1 or 4 infection, and daclatasvir/SOF/RBV for 12 weeks or SOF/RBV for 24 weeks might be effective and safe for HCV genotype 2 or 3 infection. In conclusion, current evidence supports the use of all oral DAA regimens in HCV patients with decompensated cirrhosis.

References

Aug 2, 2000·Journal of Gastroenterology and Hepatology·J H Kao, D S Chen
Jul 11, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C S WangK Richardson
Sep 20, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guadalupe Garcia-TsaoUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
May 21, 2009·The American Journal of Gastroenterology·Guadalupe Garcia-TsaoUNKNOWN Members of Veterans Affairs Hepatitis C Resource Center Program
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
Jul 15, 2011·The New England Journal of Medicine·Ching-Sheng Hsu, Jia-Horng Kao
Jul 15, 2011·The New England Journal of Medicine·Alpna R LimayeRoniel Cabrera
Mar 7, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bruce A Runyon, UNKNOWN AASLD
Aug 16, 2013·The New England Journal of Medicine·Eric Lawitz, Edward J Gane
Aug 16, 2013·The New England Journal of Medicine·Ching-Sheng Hsu
Jan 17, 2014·The New England Journal of Medicine·Mark S SulkowskiUNKNOWN AI444040 Study Group
Apr 10, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul MartinMichael Fallon
Jul 20, 2014·JAMA : the Journal of the American Medical Association·Mark S SulkowskiUNKNOWN PHOTON-1 Investigators
Nov 12, 2014·The New England Journal of Medicine·Paul Y KwoXavier Forns
Apr 8, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David WylesEric Lawitz
May 6, 2015·JAMA : the Journal of the American Medical Association·Andrew J MuirPhilip D Yin
May 13, 2015·Scientific Reports·Ching-Sheng HsuJia-Horng Kao
May 20, 2015·Gastroenterology·Michael CharltonUNKNOWN SOLAR-1 Investigators
Jun 26, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·UNKNOWN AASLD/IDSA HCV Guidance Panel
Jul 22, 2015·The New England Journal of Medicine·David L WylesUNKNOWN ALLY-2 Investigators
Aug 1, 2015·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Jia-Horng Kao
Sep 4, 2015·Transplantation·Yoshihide Ueda, Shinji Uemoto
Nov 17, 2015·The New England Journal of Medicine·Michael P CurryUNKNOWN ASTRAL-4 Investigators

❮ Previous
Next ❯

Citations

Dec 5, 2017·European Journal of Gastroenterology & Hepatology·Muhammad H BashirSalman Nusrat

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation
Deepak N AmarapurkarPraful Kamani
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Angelo IacobellisAngelo Andriulli
© 2022 Meta ULC. All rights reserved