Management of infertility and prevention of ovarian hyperstimulation in women with polycystic ovary syndrome

Best Practice & Research. Clinical Obstetrics & Gynaecology
R Homburg

Abstract

Anovulatory infertility is a prevalent presenting feature of polycystic ovary syndrome (PCOS). Restoration of ovulation might be achieved by ovarian stimulation or by reducing insulin and LH concentrations. Clomiphene citrate is the first-line ovulation-inducing agent, usually followed by direct stimulation with follicle stimulating hormone (FSH), if unsuccessful. The prevalent complications of ovarian hyperstimulation syndrome and multiple pregnancies can largely be avoided by administering FSH in a low dose and individualized regimen. Hyperinsulinaemia can be corrected by weight loss or insulin-sensitizing agents, such as metformin, which alone or in combination with other agents are capable of restoring ovulation. Advice about weight loss is critical in modern management of PCOS and infertility. Laparoscopic ovarian drilling produces similar results to FSH stimulation, and in vitro fertilization/embryo transfer (IVF/ET)-if all else fails-produces excellent results. The possible use of aromatase inhibitors, novel insulin sensitizers and in vitro maturation of oocytes is still being evaluated. The plethora of treatment options available today ensures that the great majority of women who are subfertile due to PCOS can be treate...Continue Reading

References

Sep 1, 1990·Baillière's Clinical Obstetrics and Gynaecology·D Hamilton-Fairley, S Franks
Jan 1, 1989·The Journal of Clinical Endocrinology and Metabolism·R PasqualiL Barbara
Sep 1, 1987·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M G Hull
Apr 1, 1981·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Y Z Diamant, S Evron
Apr 1, 1996·Baillière's Clinical Endocrinology and Metabolism·B W Donesky, E Y Adashi
Nov 1, 1996·The Journal of Clinical Endocrinology and Metabolism·D M WhiteS Franks
Sep 1, 1997·Obstetrics and Gynecology·E VelázquezS G Mendoza
Feb 19, 1998·The Journal of Clinical Endocrinology and Metabolism·M Van Der MeerJ Schoemaker
Jun 25, 1998·The New England Journal of Medicine·J E NestlerR Pasquali
Aug 24, 1999·Endocrine Reviews·L PoretskyL C Giudice
Jan 11, 2000·Baillière's Clinical Obstetrics and Gynaecology·R Homburg
Feb 12, 2002·The Journal of Clinical Endocrinology and Metabolism·Richard FlemingNaveed Sattar
Oct 18, 2002·Obstetrics and Gynecology·Tim J ChildSeang Lin Tan
Oct 31, 2002·Human Reproduction·Charles J GlueckLuann Sieve-Smith
May 17, 2003·Fertility and Sterility·Rebecca MansfieldHelen Mason
Jul 23, 2003·Human Reproduction·S Christin-MaitreUNKNOWN Recombinant FSH Study Group
Oct 25, 2003·BMJ : British Medical Journal·Jonathan M LordRobert J Norman

❮ Previous
Next ❯

Citations

Jul 31, 2013·Journal of Assisted Reproduction and Genetics·Paul R BrezinaZeev Shoham
Sep 9, 2006·The Breast Journal·Ingrid VandenputMarie-Rose Christiaens
Jun 16, 2007·Gerontology·Stephen R Spindler, Patricia L Mote
Apr 6, 2006·Reproductive Biology and Endocrinology : RB&E·Hang YinRoger G Gosden
Jan 11, 2014·Journal of Biomedical Science·Xin LiRuijin Shao
May 10, 2011·Expert Opinion on Drug Delivery·Michel ChristenHeiko Müller
Dec 3, 2015·Women's Health·Samer TannusShahar Kol
Oct 7, 2008·Animal Reproduction Science·Atunga NyachieoThomas M D'Hooghe
Jan 31, 2006·Aging Cell·Stephen R Spindler
Sep 21, 2006·The Journal of Obstetrics and Gynaecology Research·Fazli DemirturkUnal Erkorkmaz
May 30, 2012·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Michael F CostelloHelena J Teede
Apr 1, 2015·Journal of Ovarian Research·Betul UsluogullariCelil Usluogullari
Jun 13, 2006·Best Practice & Research. Clinical Obstetrics & Gynaecology·Roger Hart, Robert Norman
Apr 6, 2006·Fertility and Sterility·Hananel HolzerTogas Tulandi
Feb 26, 2016·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Nafiye YilmazAyten Turkkani
Nov 1, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Peipei Jin, Yongyong Xie
Sep 29, 2005·Physiological Genomics·Joseph M DhahbiStephen R Spindler
Aug 31, 2019·Nursing Standard·Fiona Smith, Ailsa Sharp
Feb 13, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·C L MulderP H Andraweera
Jun 30, 2019·Medical Sciences : Open Access Journal·Michael F CostelloWilliam L Ledger
Sep 13, 2019·Medical Sciences : Open Access Journal·Michael CostelloWilliam Ledger
Dec 22, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Chiara Di TucciPierluigi Benedetti Panici

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
W R Al-OmariN Al-Hadithi
American Journal of Obstetrics and Gynecology
Mohamed F MitwallyRobert F Casper
© 2021 Meta ULC. All rights reserved