Management of inflammatory corneal melt leading to central perforation in children: a retrospective study and review of literature

Eye
A MedsingeK K Nischal

Abstract

To assess the outcome of early therapeutic penetrating keratoplasty (PKP) for corneal melt leading to perforation in children. Case notes of all the consecutive patients presenting with acute corneal perforation that underwent urgent therapeutic PKP between 2000 and 2010 to the practice of one of the authors, both NHS at Great Ormond Street Hospital for Children and private, were retrospectively reviewed. Onset of perforation, underlying cause, medical and surgical treatment, pre- and post-operative visual acuity, graft clarity, length of follow-up, and post-operative complications were recorded. Four eyes of four consecutive patients (mean age of 9.5 years and median 8.5 years, range 4-17 years) were treated for acquired acute onset corneal perforations. There were three females and one male. Etiologies included herpes simplex keratitis secondary to immune recovery disease post bone marrow transplantation, acanthamoeba keratitis, recessive dystrophic epidermolysis bullosa, and blepharokeratoconjunctivitis with acne rosacea. Pre-operative visual acuity ranged from hand movements to 6/150. All the patients had severe anterior chamber inflammation. All eyes improved in visual acuity ranging from 6/9 to 6/18 with clear grafts at l...Continue Reading

References

Jul 1, 1990·Archives of Ophthalmology·J R NobeR E Smith
Jul 1, 1989·Survey of Ophthalmology·S L PortnoyH E Kaufman
Sep 1, 1973·The British Journal of Ophthalmology·G Singh, S R Malik
Apr 1, 1967·Archives of Ophthalmology·C H DohlmanG L Sullivan
Oct 1, 1983·Ophthalmology·R R Pfister
Jun 1, 1980·American Journal of Ophthalmology·J A FogleC S Foster
Jun 1, 2000·Cornea·M LekskulP R Laibson
Nov 1, 2002·Cornea·M VanathiRasik B Vajpayee
Apr 26, 2003·The British Journal of Ophthalmology·R B VajpayeeJ S Titiyal
Jun 6, 2003·American Journal of Ophthalmology·Shigeto ShimmuraKazuo Tsubota
Aug 13, 2003·Archives of Ophthalmology·Ali Khodadoust, Ania Porazinski Quinter
Jul 13, 2005·Archives of Ophthalmology·Sonja WamsleyV Vinod Mootha
Mar 15, 2006·The British Journal of Ophthalmology·J S TitiyalR B Vajpayee
Mar 16, 2006·Eye & Contact Lens·Jolanta Bendoriene, Ursula Vogt
Aug 19, 2006·Journal of Pediatric Ophthalmology and Strabismus·Tsuyoshi YoshitaKazuhisa Sugiyama
May 16, 2007·Archives of Ophthalmology·Ching-Hsi HsiaoKen-Kuo Lin
Mar 21, 2009·Survey of Ophthalmology·M VanathiTanuj Dada
Sep 30, 2009·Acta Ophthalmologica·Gustavo SavinoTommaso Salgarello
Dec 15, 2010·American Journal of Ophthalmology·Canan Asli UtineEsen Karamursel Akpek
Feb 19, 2011·Japanese Journal of Ophthalmology·Joo Youn OhWon Ryang Wee
May 21, 2011·Current Opinion in Ophthalmology·Gerald W Zaidman
Nov 11, 2011·American Journal of Ophthalmology·Livia TeoDonald T H Tan
Nov 24, 2011·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Andrea K LeungAsim Ali
Nov 29, 2011·Survey of Ophthalmology·Vishal JhanjiRasik B Vajpayee
Mar 20, 2012·The British Journal of Ophthalmology·Anurag MathurVirender Sangwan
Apr 13, 2012·Klinische Monatsblätter für Augenheilkunde·L MüllerC Kaufmann
Apr 17, 2012·The British Journal of Ophthalmology·Samer HamadaSaaeha Rauz
Jun 5, 2012·International Ophthalmology·Prakashchand AgarwalJeewan Singh Titiyal

❮ Previous
Next ❯

Citations

Jan 25, 2020·The Journal of International Medical Research·Om Prakash PantCheng-Wei Lu
Sep 2, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Shigefumi TakahashiKazunori Miyata

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.