Abstract
To determine the success of chemo-radiotherapy for squamous cell carcinoma (SCC) of the bulbar male urethra, an uncommon but aggressive cancer usually treated by radical deforming surgery. Two men, aged 42 and 49 years, with locally advanced SCC of the proximal deep urethra were treated with a modified Nigro chemo-radiation protocol. The initial treatment was by suprapublic cystotomy urinary diversion followed by 45 Gy in 25 fractions over 5 weeks to the penis, perineum and regional lymphatics. Chemotherapy consisted of a single intravenous dose of mitomycin C (10 mg/m2) and an intravenous infusion of 5-fluorouracil (1 g/m2/day) for 96 h starting on the first day of radiation therapy and repeated 28 days later. Follow-up evaluation with urethral biopsies, retrograde urethrography, computed tomography of the pelvis and cysto-urethroscopy under anaesthesia showed no residual tumour in either patient but the development of a proximal urethral stricture at 1.5 and 4 years, respectively. This report presents the first evidence of a successful reduction of tumour stage with the local eradication of invasive SCC and penile preservation with no recurrence of the tumour or the need to excise the urethra.
Citations
Feb 3, 2007·International Urology and Nephrology·Ali AyyildizHüseyin Ustün
Mar 10, 2009·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·F IborraUNKNOWN les membres du sous-comité organes génitaux externes du comité de cancérologie de l'AFU
Feb 5, 1999·Urology·J W DavisS M Schlossberg
Jun 15, 1999·Urology·G DalbagniH W Herr
Aug 3, 2010·The Urologic Clinics of North America·Bridget F Koontz, W Robert Lee
Dec 14, 2007·The Journal of Urology·Michael S CohenLeonard Zinman
Jul 13, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Yuvaraja B ThyavihallySrinivas G Raibhattanavar
Jun 1, 2011·Cancer·Farhang Rabbani
Nov 7, 2001·The Journal of Urology·D KentL L Pisters
Dec 19, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Mohammad AhmadiSeyed Jalal Hosseinimehr
Aug 5, 2014·The Journal of Urology·Marissa KentAlex Vanni
Aug 31, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sameer MemonAlexander G Heriot
Feb 24, 2007·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Octavio A CastilloGonzalo Vitagliano
Dec 10, 2003·American Journal of Clinical Oncology·Tony Y EngClifton D Fuller
Jul 9, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Koji MitsuzukaYoichi Arai
Feb 21, 2021·Journal of Medical Case Reports·Emily WalshIvor Cullen