Management of ischaemic heart disease in diabetic patients--is there a role for cardiac metabolic agents?

Current Medical Research and Opinion
M Marzilli

Abstract

Diabetes mellitus (DM) increases the risk of cardiovascular events in patients with cardiovascular disease as well as in patients without any previous history of ischaemic heart disease (IHD). The management of IHD in diabetic patients remains a difficult challenge. However, some of these treatments are not as effective or well-tolerated in diabetic patients as in non-diabetic patients. An important effect of diabetes, that in turn influences cardiac function, is the switch from carbohydrate oxidation to free fatty acid and ketone oxidation. The correction of the alterations to cardiac metabolism associated with DM may represent a new approach to the management of IHD in these patients. Results obtained in anginal patients with the metabolic agent trimetazidine and in infarcted patients with glucose-insulin-potassium (GIK) are consistent with this hypothesis.

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Citations

Apr 28, 2005·The Annals of Thoracic Surgery·Chandrasahekhar KubalJohn A C Chalmers
Aug 17, 2004·The Medical Clinics of North America·W H Wilson TangJames B Young
Dec 19, 2002·Current Medical Research and Opinion·Lech PolońskiKrzysztof Wilczek
Nov 11, 2003·Current Medical Research and Opinion·Mario Marzilli

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