PMID: 1908176Mar 1, 1991Paper

Management of IUD-associated menorrhagia in female rhesus monkeys (Macaca mulatta)

Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception
M Barthwal, K Srivastava


The study was undertaken to evaluate the effect of antifibrinolytic agents (epsilon-aminocaproic acid, EACA; tranexamic acid, AMCA), anti-inflammatory drugs (indomethacin, IND; ibuprofen, IBU; naproxen, NAP) and root extract of the plant Boerhaavia diffusa (BD) on menstrual cycle length (MCL), duration of menstrual flow (DMF), menstrual iron loss (MIL) and activity of uterine tissue plasminogen activator (tPA) in IUD-fitted monkeys. Premature onset of menstruation was observed in IUD-fitted monkeys (26.0 +/- 0.7 days, mean +/- SE) as compared to controls (28.7 +/- 0.4 days). No noteworthy change was observed in the MCL of drug treated monkeys as compared to IUD-fitted monkeys. An increase of 155%, 123.2%, and 288% was observed in the DMF, MIL and tPA activity after IUD insertion as compared to controls. Antifibrinolytic agents reduced the DMF, MIL and activity of tPA in IUD-fitted monkeys up to 117.4%, 116.4%, and 254%, whereas anti-inflammatory drugs caused a decrease only up to 69%, 95.1%, and 138%, respectively. Conclusively, root extract of B. diffusa treated IUD-fitted monkeys showed noticeable reduction in their DMF (124%), MIL (120.8%) and tPA activity (272%).


Dec 1, 1977·Fertility and Sterility·P F TauberL J Zaneveld
Sep 1, 1975·Contraception·P LiedholmL Sölvell
Oct 4, 1975·British Medical Journal·J M Kasonde, J Bonnar
Jun 1, 1990·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·M Barthwal, K Srivastava
Oct 1, 1987·American Journal of Obstetrics and Gynecology·J M VargyasD R Mishell
Dec 1, 1973·American Journal of Obstetrics and Gynecology·K G Nygren, E D Johansson
Feb 1, 1970·Biochemical Medicine·J D Thomas
Jun 1, 1980·Obstetrical & Gynecological Survey·R R Chaudhury
May 1, 1982·Obstetrical & Gynecological Survey·G C ChristiaensA A Haspels

Related Concepts

Anti-Inflammatory Agents
Plasmin Inhibitor
Ibuprofen, Copper (2+) Salt
Unmedicated IUDs
Macaca mulatta
Ovarian Cycle

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