PMID: 1908176Mar 1, 1991Paper

Management of IUD-associated menorrhagia in female rhesus monkeys (Macaca mulatta)

Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception
M Barthwal, K Srivastava

Abstract

The study was undertaken to evaluate the effect of antifibrinolytic agents (epsilon-aminocaproic acid, EACA; tranexamic acid, AMCA), anti-inflammatory drugs (indomethacin, IND; ibuprofen, IBU; naproxen, NAP) and root extract of the plant Boerhaavia diffusa (BD) on menstrual cycle length (MCL), duration of menstrual flow (DMF), menstrual iron loss (MIL) and activity of uterine tissue plasminogen activator (tPA) in IUD-fitted monkeys. Premature onset of menstruation was observed in IUD-fitted monkeys (26.0 +/- 0.7 days, mean +/- SE) as compared to controls (28.7 +/- 0.4 days). No noteworthy change was observed in the MCL of drug treated monkeys as compared to IUD-fitted monkeys. An increase of 155%, 123.2%, and 288% was observed in the DMF, MIL and tPA activity after IUD insertion as compared to controls. Antifibrinolytic agents reduced the DMF, MIL and activity of tPA in IUD-fitted monkeys up to 117.4%, 116.4%, and 254%, whereas anti-inflammatory drugs caused a decrease only up to 69%, 95.1%, and 138%, respectively. Conclusively, root extract of B. diffusa treated IUD-fitted monkeys showed noticeable reduction in their DMF (124%), MIL (120.8%) and tPA activity (272%).

References

Dec 1, 1977·Fertility and Sterility·P F TauberL J Zaneveld
Sep 1, 1975·Contraception·P LiedholmL Sölvell
Oct 4, 1975·British Medical Journal·J M Kasonde, J Bonnar
Jun 1, 1990·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·M Barthwal, K Srivastava
Oct 1, 1987·American Journal of Obstetrics and Gynecology·J M VargyasD R Mishell
Dec 1, 1973·American Journal of Obstetrics and Gynecology·K G Nygren, E D Johansson
Feb 1, 1970·Biochemical Medicine·J D Thomas
Jun 1, 1980·Obstetrical & Gynecological Survey·R R Chaudhury
May 1, 1982·Obstetrical & Gynecological Survey·G C ChristiaensA A Haspels

Related Concepts

Anti-Inflammatory Agents
Plasmin Inhibitor
Endometrium
Ibuprofen, Copper (2+) Salt
Osmosin
Unmedicated IUDs
Iron
Macaca mulatta
Menorrhagia
Ovarian Cycle

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.