PMID: 26883849Feb 18, 2016Paper

Management of large hepatocellular carcinoma by sequential transarterial chemoembolization and portal vein embolization: a systematic review of the literature

Minerva chirurgica
Tullio PiardiDaniele Sommacale

Abstract

Currently, the treatment of HCC is multidisciplinary. Surgery remains the gold standard although the management of large hepatocellular carcinoma remains challenging. Hepatic resection is increasingly performed with ever-expanding indications. However, postoperative liver failure remains a major cause of death after major hepatic resections. The purpose of this review is to report the results of large hepatocellular carcinoma (>5 cm or more nodules in the same lobe) management using sequential transarterial chemoembolization (TACE) and portal vein embolization (PVE) before major liver resections. A literature search was performed using PubMed, Scopus, and Web of Science (WoS) from cited English publications. The search was last conducted in December 2014. Search phrases included "hepatocellular carcinoma", "liver resection", "transarterial chemoembolization", and "portal vein embolization". Clinical and survival parameters were extracted. When there was more than one publication from the same surgical team and/or authors, only the last publication in chronological order was considered for the study. Case reports, abstracts, letters, editorials, and expert opinions were not considered for the drafting of the study. After applica...Continue Reading

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