Management of Lassa Fever: A Current Update.

Curēus
Ammar AlliTaras Halan

Abstract

Lassa fever (LF) is on the top-priority infections list of both the Food and Drug Administration (FDA) and World Health Organization (WHO). This review explores the different treatment approaches found in the literature within the last 20 years. Even though ribavirin stands out among medication options, only one clinical trial was done to assess its efficacy in humans, which necessitated that we look in-depth about the latest updates in managing LF infection. For that matter, we used a Medical Subject Headings (MeSH) search on PubMed. Inclusion criteria included papers written in the English language and human subjects. Intravenous (IV) ribavirin is the most effective treatment for an acute infection. Post-exposure prophylaxis with oral ribavirin is recommended. There is not sufficient evidence to recommended convalescent plasma for the treatment of Lassa fever. LF continues to be left in the shade from global and scientific attention despite experts expecting a rise in current and future infections due to the Lassa fever virus (LFV).

References

Aug 1, 1992·Antiviral Research·S P Fisher-HochJ Huggins
Jan 2, 1986·The New England Journal of Medicine·J B McCormickR Belmont-Williams
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·J D FrameL Pinneo
Feb 5, 2002·Microbes and Infection·Herbert SchmitzAchim Hoerauf
Mar 20, 2002·Antiviral Chemistry & Chemotherapy·R C TamZ Hong
May 15, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Walter H HaasStephan Günther
Nov 10, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel G BauschJuan J L Lertora
Feb 4, 2011·Journal of the National Medical Association·Vincent Idemyor
Nov 30, 2011·Future Microbiology·Brian B Gowen, Mike Bray
Dec 4, 2012·Viruses·Igor S Lukashevich
Jul 23, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Nnennaya A AjayiKingsley N Ukwaja
Mar 22, 2014·PLoS Neglected Tropical Diseases·Jeffrey G ShafferUNKNOWN Viral Hemorrhagic Fever Consortium
Mar 8, 2017·Disaster and Military Medicine·Tal Brosh-Nissimov
Oct 12, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Vanessa N RaabeUNKNOWN Emory Serious Communicable Diseases Unit
Dec 22, 2017·American Journal of Public Health·Maryam Ibrahim BubaAbdulsalami Nasidi
Feb 1, 2019·Journal of Virology·C E HulsebergJ M White
May 21, 2019·Emerging Infectious Diseases·Elsie A IloriUNKNOWN Nigeria Lassa Fever National Response Team
Sep 14, 2019·Current Opinion in Virology·Anise N HappiRandal J Schoepp
Nov 2, 2019·Infectious Disease Clinics of North America·Danny A AsogunAlimuddin Zumla

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