Management of leptomeningeal metastases: Prognostic factors and associated outcomes

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Jeffrey V BrowerH Ian Robins

Abstract

Limited data are currently available to direct treatment recommendations in the management of leptomeningeal metastases (LM). Here we review treatment modalities clinicians should understand in order to manage patients with LM. We first describe our institution's experience with the treatment of LM and use this dataset to frame the discussion of LM management. Between 1999 and 2014, 1361 patients with central nervous system metastases were reviewed, 124 (9.1%) had radiographic evidence of LM, and these patients form the cohort for this analysis. Mean age at diagnosis of LM was 52years. Median survival for the entire cohort was 2.3months. The most common primary malignancies were non-small cell lung cancer (25.8%), breast cancer (17.7%), small cell lung cancer (16.9%) and melanoma (8.9%). Univariate analyses demonstrated that greater Karnofsky Performance Status (KPS) (p=0.001) and administration of systemic chemotherapy (p<0.001) resulted in improved median survival. Multivariate Cox analyses revealed that receipt of chemotherapy and a complete course of whole brain radiotherapy (WBRT) (median dose 30Gy in 10 fractions, range 24-40Gy) were predictive of longer survival, (p=0.013 and 0.019, respectively). These data suggest that...Continue Reading

References

May 24, 2001·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·B HermannM L Sautter-Bihl
Sep 1, 2004·Journal of the Neurological Sciences·Ulrich HerrlingerMichael Weller
Dec 2, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·W BoogerdCh J Vecht
May 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marc C Chamberlain
Apr 25, 2006·Lancet Neurology·Beate Gleissner, Marc Charles Chamberlain
Jul 13, 2006·The Neurologist·Marc C Chamberlain
Aug 19, 2008·Neuro-oncology·Laura HarstadMorris D Groves
Jan 14, 2010·Journal of Gastrointestinal Cancer·Anna MinchomRiyaz Shah
Aug 7, 2010·Current Opinion in Oncology·Marc C Chamberlain
Nov 18, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Patrick G MorrisAntonio M Omuro
Aug 15, 2014·Journal of Korean Medical Science·Jeanny KwonSung W Ha

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Citations

Oct 25, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yang-Si LiYi-Long Wu
Dec 2, 2017·Journal of Neuro-oncology·Mark T J van BusselDieta Brandsma
Nov 2, 2018·Brain Tumor Research and Treatment·Hyojeong Kim, Eun Mi Lee
Nov 3, 2016·Current Opinion in Neurology·Emilie Le Rhun, Evanthia Galanis
Dec 6, 2019·Frontiers in Oncology·Samantha M Buszek, Caroline Chung
Aug 25, 2018·Frontiers in Oncology·Ana TurkajSilvia Novello
Jan 31, 2019·Oxford Medical Case Reports·Jessica LittleWaqar Saleem
Nov 14, 2018·Cancer Gene Therapy·Darshini KuruppuKenneth K Tanabe
Dec 4, 2019·Indian Journal of Cancer·Shekar Patil, Krishna Kumar Rathnum
Mar 9, 2019·Journal of Neuro-oncology·Sherise D FergusonIsabella C Glitza
Feb 5, 2019·Neuro-oncology·Emilie Le RhunUNKNOWN European Organisation for Research and Treatment of Cancer (EORTC) Brain Tumor Group (BTG) Central Nervous System (CNS) Meta
Jan 24, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Priya KumthekarNuhad Ibrahim
Nov 21, 2020·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Tomohiro Hosoda, Makoto Katayama
Nov 18, 2020·International Journal of Molecular Sciences·Alessia PellerinoRoberta Rudà
May 7, 2021·Nature Reviews. Cancer·Andrew E WhiteleyDorothy A Sipkins
Jul 27, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jimmy RuizRoy E Strowd

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