Management of lethal recessive alleles in beef cattle through the use of mate selection software

Genetics, Selection, Evolution : GSE
Lindsay R UppermanAlison Louise Van Eenennaam

Abstract

Recessive loss-of-function (LOF) alleles at genes which are essential for life, can result in early embryonic mortality. Cattle producers can use the LOF carrier status of individual animals to make selection and mate allocation decisions. Two beef cattle breeding strategies i.e. (1) selection against LOF carriers as parents and (2) simultaneous selection and mate allocation to avoid the occurrence of homozygous offspring in three scenarios, which differed in number and frequency of LOF alleles were evaluated using the mate selection program, MateSel. Scenarios included (a) seven loci with high-frequency LOF alleles, (b) 76 loci with low-frequency LOF alleles, and (c) 50 loci with random high- and low-frequency LOF alleles. In addition, any savings resulting from the information obtained by varying the percentage (0-100%) of the herd genotyped, together with segregation analysis to cover ungenotyped animals, were calculated to determine (1) which percentage optimized net profit for a fixed cost of genotyping ($30/test), and (2) the breakeven cost for genotyping. With full knowledge of the LOF alleles carried by selection candidates, the most profitable breeding strategy was always simultaneous selection and mate allocation to a...Continue Reading

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Citations

Apr 19, 2019·Genetics, Selection, Evolution : GSE·Martin JohnssonJohn M Hickey
Apr 4, 2021·Animals : an Open Access Journal From MDPI·Imtiaz A S RandhawaRussell E Lyons

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Methods Mentioned

BETA
Genotyping

Software Mentioned

MateSel
LethalA
PopSNP
Geneprob

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