Management of locoregional stage esophageal cancer: a single center experience

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
M M JavleH R Nava

Abstract

Therapeutic options for locoregional esophageal cancer (EC) include primary surgery, neoadjuvant or definitive chemoradiation and systemic chemotherapy. The role of surgery in these multimodal strategies has recently been debated and definitive chemoradiation is being offered as an alternative to surgery at many centers. We examined our results with multimodal therapy and surgery in this patient population. We conducted a retrospective analysis of 172 patients with locoregional (AJCC stages I-III) EC treated at RPCI between February 14, 1990 and September 20, 2002. Median age was 65 years (range, 36-95); there were 136 male patients. There were 100 regional (stages IIB-III), 69 local (stages I-IIA) and three in situ cases. Initial therapy was either combined modality (n = 122) or single modality (surgery) (n = 50). There was 0%, 30-day, postoperative mortality. Median survival for all patients was 25.3 months and was better for local stage with surgery alone (75 months) than with neoadjuvant (35.7 months) or definitive chemoradiation (19.1 months, P < 0.001). Survival for patients with regional disease treated with surgery alone, neoadjuvant or definitive chemoradiation was 21.5, 24.4 and 11.8 months, respectively (P = not sign...Continue Reading

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Citations

Jul 26, 2017·Annals of Surgery·Styliani MantziariUNKNOWN FREGAT working group – FRENCH – AFC
Jun 11, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Saubhagya Kumar Jena, Sushree Samiksha Naik
Apr 1, 2021·Journal of Gastrointestinal Cancer·Nida AkgulMehmet Cetin Kotan

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