Abstract
Therapeutic options for locoregional esophageal cancer (EC) include primary surgery, neoadjuvant or definitive chemoradiation and systemic chemotherapy. The role of surgery in these multimodal strategies has recently been debated and definitive chemoradiation is being offered as an alternative to surgery at many centers. We examined our results with multimodal therapy and surgery in this patient population. We conducted a retrospective analysis of 172 patients with locoregional (AJCC stages I-III) EC treated at RPCI between February 14, 1990 and September 20, 2002. Median age was 65 years (range, 36-95); there were 136 male patients. There were 100 regional (stages IIB-III), 69 local (stages I-IIA) and three in situ cases. Initial therapy was either combined modality (n = 122) or single modality (surgery) (n = 50). There was 0%, 30-day, postoperative mortality. Median survival for all patients was 25.3 months and was better for local stage with surgery alone (75 months) than with neoadjuvant (35.7 months) or definitive chemoradiation (19.1 months, P < 0.001). Survival for patients with regional disease treated with surgery alone, neoadjuvant or definitive chemoradiation was 21.5, 24.4 and 11.8 months, respectively (P = not sign...Continue Reading
References
Jun 11, 1992·The New England Journal of Medicine·A HerskovicB Emami
Apr 30, 1999·The Journal of Thoracic and Cardiovascular Surgery·J J NigroC G Bremner
Sep 24, 1999·Annals of Surgery·M B OrringerM D Iannettoni
Sep 13, 2001·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·H Udagawa, H Akiyama
Jan 5, 2002·The European Journal of Surgery = Acta Chirurgica·C WaltherT Möller
Jun 18, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nikhil I KhushalaniLawrence Leichman
Aug 9, 2002·The Journal of Thoracic and Cardiovascular Surgery·Manjit S BainsDavid H Ilson
Aug 10, 2002·Annals of Surgery·Nasser AltorkiJeffrey Port
Nov 22, 2002·The New England Journal of Medicine·Jan B F HulscherJ Jan B van Lanschot
Feb 6, 2003·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jun 28, 2003·International Journal of Radiation Oncology, Biology, Physics·Mohan SuntharalingamUNKNOWN 1996-1999 Patterns of Care Study
Jul 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David H IlsonBruce D Minsky
Apr 15, 2004·American Journal of Clinical Pathology
Jun 16, 2004·Annals of Surgical Oncology·R IyerM Javle
Citations
Jun 16, 2004·Annals of Surgical Oncology·R IyerM Javle
Aug 28, 2007·World Journal of Surgery·Akira OokiMasahiko Watanabe
Jun 24, 2010·Cancer Treatment Reviews·Paul McCannDevidas Menon
Jul 26, 2017·Annals of Surgery·Styliani MantziariUNKNOWN FREGAT working group – FRENCH – AFC
Jun 11, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Saubhagya Kumar Jena, Sushree Samiksha Naik
Jan 5, 2019·World Journal of Surgery·Daan M VoetenDonald L van der Peet
Apr 1, 2021·Journal of Gastrointestinal Cancer·Nida AkgulMehmet Cetin Kotan