Management of metabolic syndrome and cardiovascular risk after liver transplantation

The Lancet. Gastroenterology & Hepatology
Evangelia M Fatourou, Emmanuel A Tsochatzis

Abstract

Cardiovascular events are the second most prevalent cause of non-hepatic mortality in liver transplant recipients. The incidence of these events is projected to rise because of the growing prevalence of non-alcoholic steatohepatitis as a transplant indication and the ageing population of liver transplant recipients. Recipients with metabolic syndrome are up to four times more likely to have a cardiovascular event than recipients without, therefore prevention and optimal treatment of the components of metabolic syndrome are key in reducing the risk of these events. Although data on the treatment of metabolic comorbidities specifically in liver transplant recipients are scarce, there is detailed guidance from learned societies that mostly mirrors the guidance for patients at increased cardiovascular risk in the general population. In this Review, we discuss the management of the components of metabolic syndrome following liver transplantation and provide practical stepwise guidance. We also emphasise the need for adequately powered studies for the treatment of metabolic comorbidities in liver transplant recipients.

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Citations

Jan 15, 2021·World Journal of Hepatology·Madeleine G Gill, Avik Majumdar
Mar 2, 2021·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·Lynsey N SpillmanAngela M Madden
Mar 4, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Trevor J WilkeCale A Kassel
Jul 27, 2021·Clinics and Research in Hepatology and Gastroenterology·François VilleretDomitille Erard-Poinsot

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