Management of multifocal primary cutaneous CD30 anaplastic large cell lymphoma

Journal of the American Academy of Dermatology
James M ShehanIftikhar Ahmed

Abstract

Primary cutaneous CD30(+) anaplastic large cell lymphoma in adults is rare, but the prognosis is generally excellent. Skin lesions may be localized or, less commonly, multifocal. Although not extensively reported, multifocal primary cutaneous anaplastic large cell lymphoma tends to relapse after systemic chemotherapy and is generally considered more prone to progress to extracutaneous involvement than the localized disease. We report the case of a 21-year-old woman with primary cutaneous CD30(+) anaplastic large cell lymphoma manifesting as widespread papules and nodules. Despite remaining localized to the skin, the disease relapsed after multiple chemotherapy regimens and autologous stem-cell transplantation. Treatment with an experimental anti-CD30 monoclonal antibody was successful. Review of this case and similar cases illustrates that traditional combination chemotherapy may not be best. Newer treatments, including anti-CD30 monoclonal antibodies, show promise. However, further study is needed to develop optimal therapeutic strategies.

References

Nov 1, 1992·The British Journal of Dermatology·J U RijlaarsdamR Willemze
Feb 1, 1991·Journal of Clinical Pathology·S S BanerjeeM Harris
Feb 12, 1998·The Australasian Journal of Dermatology·P ArtemiW Regan
Oct 26, 2000·Journal of the American Academy of Dermatology·H S ZackheimM Kashani-Sabet

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Citations

Aug 19, 2011·Current Hematologic Malignancy Reports·Madeleine Duvic
Jul 1, 2010·The Indian Journal of Surgery·S Devaji RaoMeera Govindarajan
Jul 4, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·David G LottJay K Roberts
May 10, 2011·American Journal of Clinical Oncology·Edward PerryImad A Tabbara
Jul 16, 2010·Clinical Nuclear Medicine·William Makis, Robert Lisbona
Mar 5, 2010·Pediatric Dermatology·Reena Vaid, Bernard Cohen
Oct 11, 2008·Journal of Dermatological Case Reports·Melanie Pauline G Chao-LoRolando A Lopez
Nov 19, 2010·Cutaneous and Ocular Toxicology·Gulsum GencoglanKamer Gunduz
Nov 3, 2010·Actas dermo-sifiliográficas·E SimalR Baldellou
Mar 30, 2007·The Journal of Investigative Dermatology·Chalid AssafHorst Dürkop
Nov 2, 2007·Journal of the American Academy of Dermatology·Yoshiki TokuraMasahiro Takigawa
Apr 25, 2012·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Nina BookenClaus-Detlev Klemke
Feb 4, 2012·Clinical and Experimental Dermatology·J ChiaW J Loo
Oct 7, 2011·International Journal of Dermatology·Engin KocabaşKamer Gündüz
Apr 25, 2006·Journal of the American Academy of Dermatology·Jonathan E BlumeRichard T Cheney
Oct 5, 2015·Dermatologic Clinics·Lauren C Hughey
Apr 10, 2017·The Journal of Dermatology·Hiroshi SarutaTakekuni Nakama
Aug 2, 2006·The Oncologist·Eric Jacobsen
Nov 7, 2009·Journal of Cutaneous Pathology·Monia TangourNidhameddine Kchir
May 22, 2020·Current Hematologic Malignancy Reports·Cosimo Di RaimondoFarah R Abdulla

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