Nov 1, 1979

Management of necrotizing vasculitis with colchicine. Improvement in patients with cutaneous lesions and Behcet's syndrome

Archives of Dermatology
P G Hazen, B Michel

Abstract

Six patients with necrotizing vasculitis were treated with oral colchicine as part of an open study. Four patients with cutaneous vasculitis and normal levels of serum complement and one patient with vasculitis associated with Behcet's syndrome demonstrated clinical improvement while receiving colchicine. One patient with cryoglobulinemia, hypocomplementemia, and cutaneous vasculitis showed no response to colchicine therapy. In three patients, clinical improvement persisted after its withdrawal. Colchicine may be effective in controlling cutaneous necrotizing vasculitis and Behcet's syndrome through its effect on polymorphnuclear leukocyte function.

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Mentioned in this Paper

Vasculitis
Vasculitis of the Skin
Hypocomplementaemia
Necrotizing Cutaneous Vasculitis
Leukocytes
Necrotizing Vasculitis
Bahemuka Brown Syndrome
Cryoglobulinemia
Colchicine, (R)-Isomer
Colchicine

About this Paper

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