Management of Non-alcoholic Fatty Liver Disease and Steatohepatitis

Journal of Clinical and Experimental Hepatology
Thuy-Anh Le, Rohit Loomba

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of abnormal liver enzymes and chronic liver disease in the US with expected rise in incidence paralleling the epidemic of obesity. A subset of patients with NAFLD have the progressive form of NAFLD that is termed non-alcoholic steatohepatitis (NASH), which is characterized by specific features on liver histology including hepatocellular ballooning degeneration, lobular inflammation, and zone-3 steatosis with or without peri-sinusoidal fibrosis. Non-alcoholic steatohepatitis can progress to cirrhosis and result in liver-related death. Insulin resistance is commonly seen in patients with NASH and often co-exists with other features of the metabolic syndrome including hypertension, hyperlipidemia, and obesity. Although weight loss through lifestyle modifications including dietary changes and increased physical exercise remains the backbone of management of NASH, it has proved challenging for patients to achieve and maintain weight loss goals. Thus, it is often necessary to couple lifestyle changes with another pharmacologic treatment for NASH. Insulin sensitizers including the biguanides (metformin), thiazolidinediones (pioglitazone and rosiglitazone), and glucagon...Continue Reading

Citations

Apr 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Priscila Silva FigueiredoPriscila Aiko Hiane
Nov 8, 2017·Clinical and Experimental Pharmacology & Physiology·Thekkuttuparambil Ananthanarayanan Ajith
Apr 11, 2014·Current Opinion in Gastroenterology·Michelle Pearlman, Rohit Loomba
Oct 2, 2019·Archives of Pharmacal Research·Jin LeeYoon Seok Roh
Feb 21, 2019·Acta Cirúrgica Brasileira·Francisco Heine Ferreira MachadoManoel Odorico de Moraes Filho
Jul 8, 2020·International Journal of Molecular Sciences·Da Eun KimSung Yeon Kim
Nov 26, 2016·Archives of Pharmacal Research·Mi-Kyung KimMoon-Ho Son

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