Management of NSAID-associated peptic ulcer disease

Expert Review of Gastroenterology & Hepatology
Luigi MelcarneXavier Calvet

Abstract

Non-steroidal anti-inflammatory drug (NSAID) use increases the risk of gastrointestinal complications such as ulcers or bleeding. The presence of factors like advanced age, history of peptic ulcer, Helicobacter pylori infection and the use of anticoagulants or antiplatelet agents increase this risk further. COX-2 inhibitors and antisecretory drugs, particularly proton pump inhibitors, help to minimize the risk of gastrointestinal complications in high-risk patients. This review presents a practical approach to the prevention and treatment of NSAID-associated peptic ulcer disease and examines the new advances in the rational use of NSAIDs.

Associated Clinical Trials

Nov 20, 2019·Zeinab Nasr El Din Ahmed

References

Sep 10, 1992·The New England Journal of Medicine·M C AllisonR I Russell
Apr 1, 1991·Alimentary Pharmacology & Therapeutics·M RobinsonA R Euler
Feb 1, 1986·Digestive Diseases and Sciences·D E WilsonM Noar
Oct 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M ValentiniI Grazioli
Dec 2, 1999·JAMA : the Journal of the American Medical Association·L S SimonG S Geis
Aug 30, 2000·Clinical Therapeutics·J Horn
Nov 23, 2000·The New England Journal of Medicine·C BombardierUNKNOWN VIGOR Study Group
Aug 18, 2001·Digestive Diseases and Sciences·K TakeuchiK Suzuki
Jul 26, 2003·QJM : Monthly Journal of the Association of Physicians·E A J Knijff-DutmerM A F J Van de Laar
Jan 22, 2005·The New England Journal of Medicine·Francis K L ChanJoseph J Y Sung
Jan 26, 2005·Archives of Internal Medicine·Marisa BattistellaAndreas Laupacis
Jun 14, 2005·Alimentary Pharmacology & Therapeutics·M VergaraX Calvet
Aug 10, 2005·The American Journal of Gastroenterology·Angel LanasUNKNOWN Investigators of the Asociación Española de Gastroenterología (AEG)
Sep 17, 2005·Journal of Clinical Pharmacy and Therapeutics·L ChungT M Bush
Sep 27, 2005·Digestive Diseases and Sciences·Katya Gudis, Choitsu Sakamoto
Nov 8, 2005·The American Journal of Medicine·Kam-Chuen LaiShiu-Kum Lam
Dec 2, 2005·The New England Journal of Medicine·Carlo PatronoColin Baigent
Feb 24, 2006·The American Journal of Medicine·Gurkirpal SinghUNKNOWN SUCCESS-I Investigators
Feb 24, 2006·The American Journal of Gastroenterology·James M ScheimanChristopher Hawkey
Jun 27, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Kam-Chuen LaiShiu-Kum Lam
Jul 5, 2006·The American Journal of Gastroenterology·Jaroslaw RegulaRenate Fischer
Sep 2, 2006·The American Journal of Medicine·Yuhong YuanRichard H Hunt

❮ Previous
Next ❯

Citations

Nov 3, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Dmytro GolyshkinMykola Spivak
Feb 22, 2018·Nature Reviews. Gastroenterology & Hepatology·José B Sáenz, Jason C Mills
Mar 8, 2018·Helicobacter·Wen Zhong LiuUNKNOWN Chinese Society of Gastroenterology, Chinese Study Group on Helicobacter pylori and Peptic Ulcer
Aug 11, 2018·Geriatrics & Gerontology International·Seok-Joon YoonJeong-Hyun Kim
Aug 25, 2018·Expert Review of Clinical Pharmacology·Guillermo García-RayadoAngel Lanas
Aug 14, 2019·Clinical Endoscopy·Philip Wy Chiu
May 3, 2019·Geriatrics & Gerontology International·Seok-Joon YoonNam-Kyou Bae
Jul 9, 2021·Frontiers in Pharmacology·L McEvoyM Pirmohamed
Feb 15, 2019·Journal of Ethnopharmacology·Larissa Lucena PéricoClélia Akiko Hiruma-Lima
Aug 27, 2021·Expert Opinion on Pharmacotherapy·Taraneh MousaviMohammad Abdollahi
Nov 6, 2021·Pharmacoepidemiology and Drug Safety·Neriman Ipek KirmiziAhmet Akici

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Dewkoemar RamsoekhGuido N J Tytgat
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Jun Haeng LeeKorean Association of Gastroenterology
© 2022 Meta ULC. All rights reserved