PMID: 9444455Jan 28, 1998Paper

Management of NSAID-induced gastropathy: an economic decision analysis

Clinical Therapeutics
J L GoldsteinM S Boyd

Abstract

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a 2% to 4% annual incidence of serious gastrointestinal complications. These adverse clinical outcomes, and the strategies used to prevent their occurrence, translate into a significant economic burden. A decision-analysis model was constructed to contrast the 6-month costs associated with various approaches to preventing and managing NSAID-induced gastropathy and to evaluate the economic impact of two treatment regimens using fixed-dose formulations of diclofenac/misoprostol. After incorporating expected medical out-comes and predicted practice patterns, 6-month per-patient costs were derived from the model for each of five treatment regimens: (1) NSAID alone; (2) NSAID with a histamine2-receptor antagonist; (3) NSAID with coprescribed misoprostol; (4) diclofenac/misoprostol 50 mg/200 micrograms TID/BID; and (5) diclofenac/misoprostol 75 mg/200 micrograms BID. The combined diclofenac/misoprostol regimens demonstrated an 18.6% per-patient cost advantage compared with the combined NSAID regimens. Based on a 6-month period, this cost savings translated into a $214.00 per-patient overall cost savings ($1153.00 per patient for NSAID regimens versus $939.00 ...Continue Reading

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Citations

Feb 7, 2001·Gastroenterology Clinics of North America·M S Cappell, J R Schein
Jan 5, 2002·Gastroenterology Clinics of North America·W L Straus, J J Ofman
Oct 30, 2016·Clinical Therapeutics·Deirdre MladsiKenneth Saag
Aug 8, 2001·British Journal of Clinical Pharmacology·E RahmeJ LeLorier
Aug 4, 2010·British Journal of Community Nursing·David Cowan

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